Comparing in vivo, in vitro and in silico methods and integrated strategies for chemical assessment: Problems and prospects

Emilio Benfenati, Giuseppina Gini, Sebastian Hoffmann, Robert Luttik

Research output: Contribution to journalArticlepeer-review

Abstract

The RAINBOW workshop addressed the background for the integration of in vivo, in vitro and computer-based (in silico) methods, to facilitate the study of the toxic properties of chemicals. On the basis of these discussions, we prepared the present paper, outlining the strengths, weaknesses, opportunities and threats of each approach, both alone and integrated into a single testing strategy. The current scheme for evaluation of chemicals needs to be reshaped, in the face of the much larger numbers of chemicals which need to be examined and the availability of a diversified set of tools.

Original languageEnglish
Pages (from-to)153-166
Number of pages14
JournalATLA Alternatives to Laboratory Animals
Volume38
Issue number2
Publication statusPublished - May 2010

Keywords

  • In silico
  • In vitro
  • Integrated testing strategy
  • SWOT analysis
  • Toxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Toxicology
  • Medical Laboratory Technology

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