Comparing the prognostic value of geriatric health indicators: a population-based study

Alberto Zucchelli, Davide L Vetrano, Giulia Grande, Amaia Calderón-Larrañaga, Laura Fratiglioni, Alessandra Marengoni, Debora Rizzuto

Research output: Contribution to journalArticlepeer-review


BACKGROUND: The identification of individuals at increased risk of poor health-related outcomes is a priority. Geriatric research has proposed several indicators shown to be associated with these outcomes, but a head-to-head comparison of their predictive accuracy is still lacking. We therefore aimed to compare the accuracy of five geriatric health indicators in predicting different outcomes among older persons: frailty index (FI), frailty phenotype (FP), walking speed (WS), multimorbidity, and a summary score including clinical diagnoses, functioning, and disability (the Health Assessment Tool; HAT).

METHODS: Data were retrieved from the Swedish National Study on Aging and Care in Kungsholmen, an ongoing longitudinal study including 3363 people aged 60+. To inspect the accuracy of geriatric health indicators, we employed areas under the receiver operating characteristic curve (AUC) for the prediction of 3-year and 5-year mortality, 1-year and 3-year unplanned hospitalizations (1+), and contacts with healthcare providers in the 6 months before and after baseline evaluation (2+).

RESULTS: FI, WS, and HAT showed the best accuracy in the prediction of mortality [AUC(95%CI) for 3-year mortality 0.84 (0.82-0.86), 0.85 (0.83-0.87), 0.87 (0.85-0.88) and AUC(95%CI) for 5-year mortality 0.84 (0.82-0.86), 0.85 (0.83-0.86), 0.86 (0.85-0.88), respectively]. Unplanned hospitalizations were better predicted by the FI [AUC(95%CI) 1-year 0.73 (0.71-0.76); 3-year 0.72 (0.70-0.73)] and HAT [AUC(95%CI) 1-year 0.73 (0.71-0.75); 3-year 0.71 (0.69-0.73)]. The most accurate predictor of multiple contacts with healthcare providers was multimorbidity [AUC(95%CI) 0.67 (0.65-0.68)]. Predictions were generally less accurate among younger individuals (< 78 years old).

CONCLUSION: Specific geriatric health indicators predict clinical outcomes with different accuracy. Comprehensive indicators (HAT, FI, WS) perform better in predicting mortality and hospitalization. Multimorbidity exhibits the best accuracy in the prediction of multiple contacts with providers.

Original languageEnglish
Pages (from-to)185
JournalBMC Medicine
Issue number1
Publication statusPublished - Oct 2 2019
Externally publishedYes


  • Aged
  • Aged, 80 and over
  • Disabled Persons/statistics & numerical data
  • Female
  • Frail Elderly
  • Frailty/diagnosis
  • Geriatric Assessment/methods
  • Health Status Indicators
  • Hospitalization/statistics & numerical data
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Mortality
  • Predictive Value of Tests
  • Prognosis
  • Sweden/epidemiology


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