Comparing treatment options for chronic inflammatory neuropathies and choosing the right treatment plan

Research output: Contribution to journalReview articlepeer-review

Abstract

Introduction: Chronic inflammatory neuropathies are disorders caused by an immune response to peripheral nerve. They include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and neuropathy associated with anti-MAG IgM monoclonal gammopathy and other less frequent neuropathies. Several immune therapies have been proven to be effective in these neuropathies even if the best therapeutic option is still unsettled. Areas covered: The authors reviewed the literature to compare the efficacy and safety of currently used immune therapies in these neuropathies. The authors also analyzed the effect of other immune suppressive agents and of biological agents including rituximab, eculizumab, natalizumab, alemtuzumab and fingolimod that were found effective in other autoimmune diseases. Expert commentary: Despite the reported efficacy of a number of new immune therapies in some patients with immune mediated neuropathies, their efficacy has not been so far confirmed in randomized controlled studies. High-dose intravenous immunoglobulin (IVIg) (and subcutaneous immunoglobulin [SCIg] for maintenance treatment), steroids and plasma exchange remain the only therapy of proven efficacy in CIDP, IVIg in MMN and, with certain limits, rituximab and, occasionally plasma exchange in neuropathy associated with anti-MAG antibodies. New biological agents are also on the horizon but their efficacy needs to be proved in controlled studies.

Original languageEnglish
Pages (from-to)755-765
Number of pages11
JournalExpert Review of Neurotherapeutics
Volume17
Issue number8
DOIs
Publication statusPublished - Aug 3 2017

Keywords

  • Anti-MAG neuropathy
  • CIDP
  • immune therapies
  • IVIg
  • MMN
  • neuropathy
  • plasma exchange
  • rituximab
  • SCIg
  • steroids
  • therapy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Comparing treatment options for chronic inflammatory neuropathies and choosing the right treatment plan'. Together they form a unique fingerprint.

Cite this