Comparison between 1.5 and 3.0 tesla magnetic resonance enterography for the assessment of disease activity and complications in ileo-colonic crohn's disease

Gionata Fiorino, Cristiana Bonifacio, Mauro Padrenostro, Federica Mrakic Sposta, Antonino Spinelli, Alberto Malesci, Luca Balzarini, Laurent Peyrin-Biroulet, Silvio Danese

Research output: Contribution to journalArticle

Abstract

Background: Magnetic resonance imaging (MRI) can assess disease activity and severity in Crohn's disease (CD). Three-Tesla magnetic resonance (3T) increases signal-to-noise ratio (SNR) and reduces time of image acquisition (IAT). Whether 3T increases the accuracy of MRI in CD compared to 1.5T is unknown. Aim: We aimed to compare prospectively the accuracy of 3 and 1.5T in ileo-colonic CD patients. Methods: Twenty-six patients with ileo-colonic CD underwent 1.5 and 3T MR enterography at the same time. Ileocolonoscopy was the reference standard for luminal disease. Sensitivity, specificity and accuracy of MRI in evaluating six signs of active and complicated disease (localization, thickening, enhancement, strictures, entero-enteric fistulas, and ulcers) were calculated for both techniques. Results: Three-Tesla resulted as sensitive, specific, and accurate as 1.5T in detecting disease location (accuracy 0.93 vs. 0.86), bowel wall thickening and enhancement (accuracy 0.92 vs. 0.80 for both parameters), strictures (accuracy 0.90 vs. 0.80) and entero-enteric fistulas (accuracy 0.92 vs. 0.92). 3T was superior to 1.5T in detecting ulcers (0.76 vs. 0.42, P <0.05). SNR resulted higher in 3T, and IAT resulted shorter than 1.5. Conclusions: We found that 3T is equally accurate as 1.5T in evaluating ileo-colonic CD. Because of superiority in detecting mucosal ulcers, 3T should be preferred in patients with ileo-colonic CD.

Original languageEnglish
Pages (from-to)3246-3255
Number of pages10
JournalDigestive Diseases and Sciences
Volume58
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • 1.5 Tesla
  • 3.0 Tesla
  • Crohn's disease
  • Inflammatory bowel disease
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

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