Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo - A multicentre controlled study

M. Casacci, P. Thomas, A. Pacifico, A. Bonnevalle, A. Paro Vidolin, G. Leone

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Background: Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Recently, it has been shown that narrowband ultraviolet B (NB-UVB) phototherapy may be more effective than psoralen and ultraviolet A (PUVA) photochemotherapy in treating vitiligo, and that 308-nm monochromatic excimer light (MEL) may present some advantages as compared to NB-UVB for the treatment of vitiligo. Aim: The aim of this study was to compare the effectiveness of NB-UVB phototherapy and 308-nm MEL in vitiligo patients. Methods: The study was done in a randomized, investigator-blinded and half-side comparison design. Twenty-one subjects with symmetrical vitiligo lesions were enrolled in this study. Vitiligo lesions on one body side were treated twice weekly for 6 months with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions on the opposite side. Results: At the end of the study six lesions (37.5%) treated with 308-nm MEL and only one lesion (6%) treated with NB-UVB achieved an excellent repigmentation (score 4) while four lesions (25%) treated with 308-nm MEL and five lesions (31%) treated with NB-UVB showed a good repigmentation (score 3). Conclusions: It appears that 308-nm MEL is more effective than NB-UVB in treating vitiligo lesions and it induces repigmentation more rapidly.

Original languageEnglish
Pages (from-to)956-963
Number of pages8
JournalJournal of the European Academy of Dermatology and Venereology
Volume21
Issue number7
DOIs
Publication statusPublished - Aug 2007

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Vitiligo
Phototherapy
Multicenter Studies
Light
Therapeutics
Ficusin
Melanocytes
Photochemotherapy
Research Personnel
Skin

Keywords

  • Monochromatic excimer laser
  • Monochromatic excimer light
  • Narrowband ultraviolet B
  • Vitiligo

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Comparison between 308-nm monochromatic excimer light and narrowband UVB phototherapy (311-313 nm) in the treatment of vitiligo - A multicentre controlled study. / Casacci, M.; Thomas, P.; Pacifico, A.; Bonnevalle, A.; Paro Vidolin, A.; Leone, G.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 21, No. 7, 08.2007, p. 956-963.

Research output: Contribution to journalArticle

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abstract = "Background: Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Recently, it has been shown that narrowband ultraviolet B (NB-UVB) phototherapy may be more effective than psoralen and ultraviolet A (PUVA) photochemotherapy in treating vitiligo, and that 308-nm monochromatic excimer light (MEL) may present some advantages as compared to NB-UVB for the treatment of vitiligo. Aim: The aim of this study was to compare the effectiveness of NB-UVB phototherapy and 308-nm MEL in vitiligo patients. Methods: The study was done in a randomized, investigator-blinded and half-side comparison design. Twenty-one subjects with symmetrical vitiligo lesions were enrolled in this study. Vitiligo lesions on one body side were treated twice weekly for 6 months with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions on the opposite side. Results: At the end of the study six lesions (37.5{\%}) treated with 308-nm MEL and only one lesion (6{\%}) treated with NB-UVB achieved an excellent repigmentation (score 4) while four lesions (25{\%}) treated with 308-nm MEL and five lesions (31{\%}) treated with NB-UVB showed a good repigmentation (score 3). Conclusions: It appears that 308-nm MEL is more effective than NB-UVB in treating vitiligo lesions and it induces repigmentation more rapidly.",
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AB - Background: Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. Recently, it has been shown that narrowband ultraviolet B (NB-UVB) phototherapy may be more effective than psoralen and ultraviolet A (PUVA) photochemotherapy in treating vitiligo, and that 308-nm monochromatic excimer light (MEL) may present some advantages as compared to NB-UVB for the treatment of vitiligo. Aim: The aim of this study was to compare the effectiveness of NB-UVB phototherapy and 308-nm MEL in vitiligo patients. Methods: The study was done in a randomized, investigator-blinded and half-side comparison design. Twenty-one subjects with symmetrical vitiligo lesions were enrolled in this study. Vitiligo lesions on one body side were treated twice weekly for 6 months with 308-nm MEL, while NB-UVB phototherapy was used to treat lesions on the opposite side. Results: At the end of the study six lesions (37.5%) treated with 308-nm MEL and only one lesion (6%) treated with NB-UVB achieved an excellent repigmentation (score 4) while four lesions (25%) treated with 308-nm MEL and five lesions (31%) treated with NB-UVB showed a good repigmentation (score 3). Conclusions: It appears that 308-nm MEL is more effective than NB-UVB in treating vitiligo lesions and it induces repigmentation more rapidly.

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