Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis

E. Masci, L. Bierti, M. Guslandi, M. Sorghi, P. A. Testoni, S. Passaretti, A. Tittobello

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Medical therapy of reflux esophagitis has been mainly directed to the neutralization of refluxing acid with antacids, to the inhibition of gastric acid secretion with antisecretory drugs or to the prevention of gastro-esophageal reflux with prokinetic drugs. In the present study 43 patients with symptomatic reflux esophagitis were randomly treated with either ranitidine (150 mg b.i.d.) or antacids with a high neutralizing power (15 ml q.i.d.) or antacids plus domperidone (20 mg t.i.d.) for 8 weeks. Before and after treatment the severity of dyspeptic symptoms (heartburn, regurgitation, retrosternal pain and dysphagia) and the grade of endoscopic and histologic changes were assessed. No significant differences among the three groups were found as far improvement of symptoms and effect on endoscopic and histological features. In all groups of treatment significant better results were observed in patients who did not smoke and drink alcohol, in comparison with smoking and drinking patients (p <0.01).

Original languageEnglish
Title of host publicationDiseases of the Esophagus
Pages163-170
Number of pages8
Volume1
Edition3
Publication statusPublished - 1988

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Domperidone
Peptic Esophagitis
Antacids
Ranitidine
Heartburn
Gastric Acid
Deglutition Disorders
Gastroesophageal Reflux
Smoke
Pharmaceutical Preparations
Drinking
Therapeutics
Smoking
Alcohols
Pain
Acids
Power (Psychology)

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Masci, E., Bierti, L., Guslandi, M., Sorghi, M., Testoni, P. A., Passaretti, S., & Tittobello, A. (1988). Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis. In Diseases of the Esophagus (3 ed., Vol. 1, pp. 163-170)

Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis. / Masci, E.; Bierti, L.; Guslandi, M.; Sorghi, M.; Testoni, P. A.; Passaretti, S.; Tittobello, A.

Diseases of the Esophagus. Vol. 1 3. ed. 1988. p. 163-170.

Research output: Chapter in Book/Report/Conference proceedingChapter

Masci, E, Bierti, L, Guslandi, M, Sorghi, M, Testoni, PA, Passaretti, S & Tittobello, A 1988, Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis. in Diseases of the Esophagus. 3 edn, vol. 1, pp. 163-170.
Masci E, Bierti L, Guslandi M, Sorghi M, Testoni PA, Passaretti S et al. Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis. In Diseases of the Esophagus. 3 ed. Vol. 1. 1988. p. 163-170
Masci, E. ; Bierti, L. ; Guslandi, M. ; Sorghi, M. ; Testoni, P. A. ; Passaretti, S. ; Tittobello, A. / Comparison between an antacid with a high neutralizing power alone or in combination with domperidone and ranitidine in the treatment of symptomatic reflux esophagitis. Diseases of the Esophagus. Vol. 1 3. ed. 1988. pp. 163-170
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