Comparison between diurnal changes and changes induced by hydrocortisone and epinephrine in circulating myeloid progenitor cells (CFU-GM) in man

L. Morra, A. Ponassi, G. Caristo, P. Bruzzi, A. Bonelli, R. Zunino, G. B. Parodi, C. Sacchetti

Research output: Contribution to journalArticlepeer-review

Abstract

A significant increase from 8 AM to 3 PM was found in both myeloid progenitor cell (CFU-GM) and polymorphonuclear leukocyte (PMN) blood concentration in 45 normal subjects. Diurnal blood CFU-GM and PMN changes were significantly correlated. Spontaneous diurnal changes in blood CFU-GM levels and in PMN were compared with the changes induced by i.v. administration of hydrocortisone (16 normal volunteers) and of epinephrine (10 normal volunteers). Diurnal changes in CFU-GM and PMN seem to follow a pattern similar to that induced by epinephrine administration. These findings suggest that diurnal changes in CFU-GM reflect mainly a shift of these cells between different blood compartments.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalBiomedicine and Pharmacotherapy
Volume38
Issue number3
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmacology

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