TY - JOUR
T1 - Comparison between Early-Onset and Late-Onset Alzheimer's Disease Patients with Amnestic Presentation
T2 - CSF and 18F-FDG PET Study
AU - Chiaravalloti, A.
AU - Koch, Giacomo
AU - Toniolo, Sofia
AU - Belli, Lorena
AU - Di Lorenzo, Francesco
AU - Gaudenzi, Sara
AU - Schillaci, Orazio
AU - Bozzali, Marco
AU - Sancesario, Giuseppe
AU - Martorana, A.
PY - 2016/4/5
Y1 - 2016/4/5
N2 - Background/Aims: To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged ≤65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years). Methods: Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of Aβ1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD. Results: As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group. Conclusions: The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.
AB - Background/Aims: To investigate the differences in brain glucose consumption between patients with early onset of Alzheimer's disease (EOAD, aged ≤65 years) and patients with late onset of Alzheimer's disease (LOAD, aged >65 years). Methods: Differences in brain glucose consumption between the groups have been evaluated by means of Statistical Parametric Mapping version 8, with the use of age, sex, Mini-Mental State Examination and cerebrospinal fluid values of Aβ1-42, phosphorylated Tau and total Tau as covariates in the comparison between EOAD and LOAD. Results: As compared to LOAD, EOAD patients showed a significant decrease in glucose consumption in a wide portion of the left parietal lobe (BA7, BA31 and BA40). No significant differences were obtained when subtracting the EOAD from the LOAD group. Conclusions: The results of our study show that patients with EOAD show a different metabolic pattern as compared to those with LOAD that mainly involves the left parietal lobe.
KW - Alzheimer’s disease
KW - Cerebrospinal fluid biomarkers
KW - Early onset
KW - Late onset
KW - Precuneus
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U2 - 10.1159/000441776
DO - 10.1159/000441776
M3 - Article
SP - 108
EP - 119
JO - Dementia and Geriatric Cognitive Disorders Extra
JF - Dementia and Geriatric Cognitive Disorders Extra
SN - 1664-5464
ER -