Comparison between exercise and trans-oesophageal atrial pacing in patients with coronary artery disease: technetium-99m methoxy isobutyl isonitrile simultaneous evaluation of ventricular function and myocardial perfusion

Alberto Cuocolo, Maurizio Santomauro, Leonardo Pace, Luigi Celentano, Antonio Nappi, Emanuele Nicolai, Massimo Chiariello, Marco Salvatore

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Abstract

In this study we compared the results of exercise and trans-oesophageal atrial pacing (TAP) technetium-99m methoxyisobutyl isonitrile (99mTc-SESTAMIBI) cardiac imaging in the evaluation of left ventricular (LV) function and myocardial perfusion in patients with angiographically proven coronary artery disease. Ten patients (8 men and 2 women, mean age 59 ± 6 years) were submitted to 3 separate injections of 99mTc-SESTAMIBI, one under control conditions, one after exercise and one after TAP. LV ejection fraction, as measured by electrocardiogram (ECG) gated first pass, decreased from 49 ± 5 % under control conditions to 42 ±6% during exercise (P <0.05 versus control) and to 43 ±8 % during TAP (P99mTc-SESTAMIBI studies, 103 segments (69% of the total) were normal, 32 (21 %) had reversible, and 15 (10%) irreversible, perfusion defects. Relative regional tracer uptake was not statistically different between exercise and TAP in normal regions (91.1 ± 9.1 % versus 90.7 ± 8.5 %, respectively), in regions with reversible (61.9±12% versus 62.4±10.4%, respectively) and irreversible perfusion defects (55.8 ± 7.8 % versus 58.8 ± 9.5 %, respectively). Our results demonstrated that 99mTc-SESTAMIBI TAP cardiac imaging shows similar results to 99mTc-SESTAMIBI exercise myocardial scintigraphy in the assessment of LV function and myocardial perfusion in patients with coronary artery disease.

Original languageEnglish
Pages (from-to)119-124
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 1992

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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