Abstract
In the present study the effects of the histamine type 2 antagonist drugs famotidine (FMT) and ranitidine (RNT) on immune functions in human subjects were compared. Administration of FMT (40 mg orally) enhanced the lymphocyte responsiveness in the allogeneic mixed reaction (MLR), whereas it did not affect the lymphocyte responses to mitogens or in autologous mixed reactions (AMLRs). Administration of RNT (150 mg orally) enhanced the lymphocyte responsiveness to mitogens and in AMLRs without affecting that in MLR. The authors did not find any modification of either the absolute number of T and B eclls or the percentage of lymphocyte subsets in peripheral blood following administration of the two drugs. In conclusion, this study shows that: (a) FMT and RNT exert immunomodulatory effects in man; (b) each drug displays a different pattern of immunological activities; (c) the immunomodulatory effects seem to be related to the direct influence of the drugs on lymphocytes rather than to redistribution of lymphocyte subsets between lymphoid organs or to modifications in expression of membrane markers.
| Original language | English |
|---|---|
| Pages (from-to) | 243-248 |
| Number of pages | 6 |
| Journal | International Journal of Immunotherapy |
| Volume | 4 |
| Issue number | 4 |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Comparison between famotidine and ranitidine immunomodulatory effects in man. / Pierri, I.; Rogna, S.; Stagnaro, R.; Piovano, P. L.; Morgano, A.; Setti, M.; Picciotto, A.; Puppo, F.; Indiveri, F.
In: International Journal of Immunotherapy, Vol. 4, No. 4, 1988, p. 243-248.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison between famotidine and ranitidine immunomodulatory effects in man
AU - Pierri, I.
AU - Rogna, S.
AU - Stagnaro, R.
AU - Piovano, P. L.
AU - Morgano, A.
AU - Setti, M.
AU - Picciotto, A.
AU - Puppo, F.
AU - Indiveri, F.
PY - 1988
Y1 - 1988
N2 - In the present study the effects of the histamine type 2 antagonist drugs famotidine (FMT) and ranitidine (RNT) on immune functions in human subjects were compared. Administration of FMT (40 mg orally) enhanced the lymphocyte responsiveness in the allogeneic mixed reaction (MLR), whereas it did not affect the lymphocyte responses to mitogens or in autologous mixed reactions (AMLRs). Administration of RNT (150 mg orally) enhanced the lymphocyte responsiveness to mitogens and in AMLRs without affecting that in MLR. The authors did not find any modification of either the absolute number of T and B eclls or the percentage of lymphocyte subsets in peripheral blood following administration of the two drugs. In conclusion, this study shows that: (a) FMT and RNT exert immunomodulatory effects in man; (b) each drug displays a different pattern of immunological activities; (c) the immunomodulatory effects seem to be related to the direct influence of the drugs on lymphocytes rather than to redistribution of lymphocyte subsets between lymphoid organs or to modifications in expression of membrane markers.
AB - In the present study the effects of the histamine type 2 antagonist drugs famotidine (FMT) and ranitidine (RNT) on immune functions in human subjects were compared. Administration of FMT (40 mg orally) enhanced the lymphocyte responsiveness in the allogeneic mixed reaction (MLR), whereas it did not affect the lymphocyte responses to mitogens or in autologous mixed reactions (AMLRs). Administration of RNT (150 mg orally) enhanced the lymphocyte responsiveness to mitogens and in AMLRs without affecting that in MLR. The authors did not find any modification of either the absolute number of T and B eclls or the percentage of lymphocyte subsets in peripheral blood following administration of the two drugs. In conclusion, this study shows that: (a) FMT and RNT exert immunomodulatory effects in man; (b) each drug displays a different pattern of immunological activities; (c) the immunomodulatory effects seem to be related to the direct influence of the drugs on lymphocytes rather than to redistribution of lymphocyte subsets between lymphoid organs or to modifications in expression of membrane markers.
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M3 - Article
AN - SCOPUS:0024273382
VL - 4
SP - 243
EP - 248
JO - International Journal of Immunotherapy
JF - International Journal of Immunotherapy
SN - 0255-9625
IS - 4
ER -