Comparison between gleason score and apparent diffusion coefficient obtained from diffusion-weighted imaging of prostate cancer patients

Rocchina Caivano, Paola Rabasco, Antonella Lotumolo, Patrizia Cirillo, Felice D'Antuono, Alexis Zandolino, Antonio Villonio, Luca Macarini, Marco Salvatore, Aldo Cammarota

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To correlate the apparent diffusion coefficient (ADC) of prostate cancer patients with pathological Gleason scores (GS). Methods: 40 patients with GS 2 + 3, 3 + 3, 3 + 4, or 4 + 4 were selected. The magnetic resonance imaging (MRI) study was performed adding axial diffusion-weighted imaging (DWI) sequences to the standard MRI protocol. ADC values obtained were correlated with the GS data. Results: Statistically significant differences of ADC (p <.05) were found among GS groups with a trend of decreasing ADC values with increasing GS. Conclusions: The ADC values may help clinicians to delineate prostate carcinoma, recognizing its high- or low-grade compartments.

Original languageEnglish
Pages (from-to)625-629
Number of pages5
JournalCancer Investigation
Volume31
Issue number9
DOIs
Publication statusPublished - Nov 2013

Keywords

  • ADC
  • Diffusion-weighted imaging
  • Gleason score
  • Magnetic resonance imaging
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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