Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in post-myocardial infarction patients

Maria Vittoria Pitzalis, Filippo Mastropasqua, Andrea Passantino, Francesco Massari, Luana Ligurgo, Cinzia Forleo, Cataldo Balducci, Federico Lombardi, Paolo Rizzon

Research output: Contribution to journalArticlepeer-review

Abstract

Background - Depressed baroreflex sensitivity obtained by means of a phenylephrine test plays a prognostic role in patients with a previous myocardial infarction. Our purpose was to evaluate the correlation and agreement between the baroreflex sensitivity obtained with phenylephrine and that obtained by two noninvasive methods: the α-index and sequence analysis. Methods and Results - The α-index was measured by means of the spectral analysis of RR and systolic blood pressure variabilities in both the high- and low-frequency bands; sequences were identified from simultaneously recorded time series in which the RR and systolic blood pressure concurrently increased or decreased. Noninvasive baroreflex sensitivity tests were performed during both spontaneous and controlled respiration. Fifty-two consecutive patients with recent myocardial infarction underwent the analyses. Although the correlations between phenylephrine and either of the noninvasive methods were always significant, those found during controlled respiration had the highest r values (r = .70). However, the limits of agreement calculated by means of the Bland and Altman method were wide for both noninvasive methods. Conclusions - The results obtained by means of noninvasive baroreflex sensitivity assessments should not the used in clinical practice as an alternative to those obtained by the phenylephrine method.

Original languageEnglish
Pages (from-to)1362-1367
Number of pages6
JournalCirculation
Volume97
Issue number14
Publication statusPublished - Apr 14 1998

Keywords

  • Baroreceptors
  • Myocardial infarction
  • Phenylephrine

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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