Comparison between optimized GRE and RARE sequences for 19F MRI studies

Chiara D. Soffientini, Alfonso Mastropietro, Matteo Caffini, Sara Cocco, Ileana Zucca, Alessandro Scotti, Giuseppe Baselli, Maria Grazia Bruzzone

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In 19F-MRI studies limiting factors are the presence of a low signal due to the low concentration of 19F-nuclei, necessary for biological applications, and the inherent low sensitivity of MRI. Hence, acquiring images using the pulse sequence with the best signal to noise ratio (SNR) by optimizing the acquisition parameters specifically to a 19F compound is a core issue. In 19F-MRI, multiple-spin-echo (RARE) and gradient-echo (GRE) are the two most frequently used pulse sequence families; therefore we performed an optimization study of GRE pulse sequences based on numerical simulations and experimental acquisitions on fluorinated compounds. We compared GRE performance to an optimized RARE sequence. Images were acquired on a 7T MRI preclinical scanner on phantoms containing different fluorinated compounds. Actual relaxation times (T1, T2, T2) were evaluated in order to predict SNR dependence on sequence parameters. Experimental comparisons between spoiled GRE and RARE, obtained at a fixed acquisition time and in steady state condition, showed RARE sequence outperforming the spoiled GRE (up to 406% higher). Conversely, the use of the unbalanced-SSFP showed a significant increase in SNR compared to RARE (up to 28% higher). Moreover, this sequence (as GRE in general) was confirmed to be virtually insensitive to T1 and T2 relaxation times, after proper optimization, thus improving marker independence from the biological environment. These results confirm the efficacy of the proposed optimization tool and foster further investigation addressing in-vivo applicability.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume9033
ISBN (Print)9780819498267
DOIs
Publication statusPublished - 2014
EventMedical Imaging 2014: Physics of Medical Imaging - San Diego, CA, United States
Duration: Feb 17 2014Feb 20 2014

Other

OtherMedical Imaging 2014: Physics of Medical Imaging
CountryUnited States
CitySan Diego, CA
Period2/17/142/20/14

Fingerprint

Signal-To-Noise Ratio
Magnetic resonance imaging
echoes
Signal to noise ratio
gradients
Relaxation time
acquisition
signal to noise ratios
optimization
Biomarkers
pulses
relaxation time
Fluorine-19 Magnetic Resonance Imaging
Computer simulation
markers
scanners
low concentrations
nuclei
sensitivity
simulation

Keywords

  • Gradient Echo
  • RARE
  • sequence optimization

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Soffientini, C. D., Mastropietro, A., Caffini, M., Cocco, S., Zucca, I., Scotti, A., ... Bruzzone, M. G. (2014). Comparison between optimized GRE and RARE sequences for 19F MRI studies. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9033). [90334E] SPIE. https://doi.org/10.1117/12.2042658

Comparison between optimized GRE and RARE sequences for 19F MRI studies. / Soffientini, Chiara D.; Mastropietro, Alfonso; Caffini, Matteo; Cocco, Sara; Zucca, Ileana; Scotti, Alessandro; Baselli, Giuseppe; Bruzzone, Maria Grazia.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9033 SPIE, 2014. 90334E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Soffientini, CD, Mastropietro, A, Caffini, M, Cocco, S, Zucca, I, Scotti, A, Baselli, G & Bruzzone, MG 2014, Comparison between optimized GRE and RARE sequences for 19F MRI studies. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 9033, 90334E, SPIE, Medical Imaging 2014: Physics of Medical Imaging, San Diego, CA, United States, 2/17/14. https://doi.org/10.1117/12.2042658
Soffientini CD, Mastropietro A, Caffini M, Cocco S, Zucca I, Scotti A et al. Comparison between optimized GRE and RARE sequences for 19F MRI studies. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9033. SPIE. 2014. 90334E https://doi.org/10.1117/12.2042658
Soffientini, Chiara D. ; Mastropietro, Alfonso ; Caffini, Matteo ; Cocco, Sara ; Zucca, Ileana ; Scotti, Alessandro ; Baselli, Giuseppe ; Bruzzone, Maria Grazia. / Comparison between optimized GRE and RARE sequences for 19F MRI studies. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 9033 SPIE, 2014.
@inproceedings{6a5742551d114f45a66ec5e5610b940a,
title = "Comparison between optimized GRE and RARE sequences for 19F MRI studies",
abstract = "In 19F-MRI studies limiting factors are the presence of a low signal due to the low concentration of 19F-nuclei, necessary for biological applications, and the inherent low sensitivity of MRI. Hence, acquiring images using the pulse sequence with the best signal to noise ratio (SNR) by optimizing the acquisition parameters specifically to a 19F compound is a core issue. In 19F-MRI, multiple-spin-echo (RARE) and gradient-echo (GRE) are the two most frequently used pulse sequence families; therefore we performed an optimization study of GRE pulse sequences based on numerical simulations and experimental acquisitions on fluorinated compounds. We compared GRE performance to an optimized RARE sequence. Images were acquired on a 7T MRI preclinical scanner on phantoms containing different fluorinated compounds. Actual relaxation times (T1, T2, T2) were evaluated in order to predict SNR dependence on sequence parameters. Experimental comparisons between spoiled GRE and RARE, obtained at a fixed acquisition time and in steady state condition, showed RARE sequence outperforming the spoiled GRE (up to 406{\%} higher). Conversely, the use of the unbalanced-SSFP showed a significant increase in SNR compared to RARE (up to 28{\%} higher). Moreover, this sequence (as GRE in general) was confirmed to be virtually insensitive to T1 and T2 relaxation times, after proper optimization, thus improving marker independence from the biological environment. These results confirm the efficacy of the proposed optimization tool and foster further investigation addressing in-vivo applicability.",
keywords = "Gradient Echo, RARE, sequence optimization",
author = "Soffientini, {Chiara D.} and Alfonso Mastropietro and Matteo Caffini and Sara Cocco and Ileana Zucca and Alessandro Scotti and Giuseppe Baselli and Bruzzone, {Maria Grazia}",
year = "2014",
doi = "10.1117/12.2042658",
language = "English",
isbn = "9780819498267",
volume = "9033",
booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",

}

TY - GEN

T1 - Comparison between optimized GRE and RARE sequences for 19F MRI studies

AU - Soffientini, Chiara D.

AU - Mastropietro, Alfonso

AU - Caffini, Matteo

AU - Cocco, Sara

AU - Zucca, Ileana

AU - Scotti, Alessandro

AU - Baselli, Giuseppe

AU - Bruzzone, Maria Grazia

PY - 2014

Y1 - 2014

N2 - In 19F-MRI studies limiting factors are the presence of a low signal due to the low concentration of 19F-nuclei, necessary for biological applications, and the inherent low sensitivity of MRI. Hence, acquiring images using the pulse sequence with the best signal to noise ratio (SNR) by optimizing the acquisition parameters specifically to a 19F compound is a core issue. In 19F-MRI, multiple-spin-echo (RARE) and gradient-echo (GRE) are the two most frequently used pulse sequence families; therefore we performed an optimization study of GRE pulse sequences based on numerical simulations and experimental acquisitions on fluorinated compounds. We compared GRE performance to an optimized RARE sequence. Images were acquired on a 7T MRI preclinical scanner on phantoms containing different fluorinated compounds. Actual relaxation times (T1, T2, T2) were evaluated in order to predict SNR dependence on sequence parameters. Experimental comparisons between spoiled GRE and RARE, obtained at a fixed acquisition time and in steady state condition, showed RARE sequence outperforming the spoiled GRE (up to 406% higher). Conversely, the use of the unbalanced-SSFP showed a significant increase in SNR compared to RARE (up to 28% higher). Moreover, this sequence (as GRE in general) was confirmed to be virtually insensitive to T1 and T2 relaxation times, after proper optimization, thus improving marker independence from the biological environment. These results confirm the efficacy of the proposed optimization tool and foster further investigation addressing in-vivo applicability.

AB - In 19F-MRI studies limiting factors are the presence of a low signal due to the low concentration of 19F-nuclei, necessary for biological applications, and the inherent low sensitivity of MRI. Hence, acquiring images using the pulse sequence with the best signal to noise ratio (SNR) by optimizing the acquisition parameters specifically to a 19F compound is a core issue. In 19F-MRI, multiple-spin-echo (RARE) and gradient-echo (GRE) are the two most frequently used pulse sequence families; therefore we performed an optimization study of GRE pulse sequences based on numerical simulations and experimental acquisitions on fluorinated compounds. We compared GRE performance to an optimized RARE sequence. Images were acquired on a 7T MRI preclinical scanner on phantoms containing different fluorinated compounds. Actual relaxation times (T1, T2, T2) were evaluated in order to predict SNR dependence on sequence parameters. Experimental comparisons between spoiled GRE and RARE, obtained at a fixed acquisition time and in steady state condition, showed RARE sequence outperforming the spoiled GRE (up to 406% higher). Conversely, the use of the unbalanced-SSFP showed a significant increase in SNR compared to RARE (up to 28% higher). Moreover, this sequence (as GRE in general) was confirmed to be virtually insensitive to T1 and T2 relaxation times, after proper optimization, thus improving marker independence from the biological environment. These results confirm the efficacy of the proposed optimization tool and foster further investigation addressing in-vivo applicability.

KW - Gradient Echo

KW - RARE

KW - sequence optimization

UR - http://www.scopus.com/inward/record.url?scp=84901594064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901594064&partnerID=8YFLogxK

U2 - 10.1117/12.2042658

DO - 10.1117/12.2042658

M3 - Conference contribution

SN - 9780819498267

VL - 9033

BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

PB - SPIE

ER -