Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients

Giuseppe Derosa, Pamela Maffioli, Ilaria Ferrari, Angela D'Angelo, Elena Fogari, Ilaria Palumbo, Sabrina Randazzo, Arrigo F G Cicero

Research output: Contribution to journalArticlepeer-review

Abstract

To evaluate the effects of 1-year treatment with orlistat plus l-carnitine compared to orlistat alone on body weight, glycemic and lipid control, and inflammatory parameters in obese type 2 diabetic patients. Two hundred and fifty-eight patients with uncontrolled type 2 diabetes mellitus (T2DM) [glycated hemoglobin (HbA 1c)>8.0%] in therapy with different oral hypoglycemic agents or insulin were enrolled in this study and randomized to take orlistat 120mg three times a day plus l-carnitine 2g one time a day or orlistat 120mg three times a day. We evaluated the following parameters at baseline and after 3, 6, 9, and 12months body weight, body mass index (BMI), glycated hemoglobin (HbA 1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), adiponectin (ADN), leptin, tumor necrosis factor-α (TNF-α), vaspin, and high-sensitivity C-reactive protein (Hs-CRP). We observed a better decrease in body weight, glycemic profile, HOMA-IR, LDL-C, and ADN and a faster improvement in FPI, TC, Tg, leptin, TNF-α, Hs-CRP with orlistat plus l-carnitine compared to orlistat alone. We also recorded an improvement in vaspin with orlistat plus l-carnitine not reached with orlistat alone. Orlistat plus l-carnitine gave a better improvement in body weight, glycemic and lipid profile compared to orlistat alone; furthermore, a faster and better improvement in inflammatory parameters was observed with orlistat plus l-carnitine compared to orlistat alone.

Original languageEnglish
Pages (from-to)642-651
Number of pages10
JournalFundamental and Clinical Pharmacology
Volume25
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Inflammation
  • l-carnitine
  • Orlistat
  • TNF-α
  • Type 2 diabetes
  • Vaspin

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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