Abstract
Patients with chronic bronchitis were treated orally with either amoxicillin (500 mg) alone or in combination with carbocisteine (150 mg), thrice daily for five days, in order to assess whether the combination allows higher antibiotic levels to be obtained in bronchial mucus than those obtained from amoxicillin alone. Serum and mucus levels were determined for each patient at first and fifth day of the two drug regimens. The levels of amoxicillin in the lung tissue collected in patients undergoing pulmonary surgery were also determined after a single oral dose of amoxicillin (1 g) or of amoxicillin (1 g) plus carbocisteine (300 mg). In the bronchial secretions, at the same plasma concentrations, amoxicillin levels were statistically higher after administration of combined substances. These findings indicate the presence of a pharmacokinetic synergism between these compounds, which allows amoxicillin to penetrate more easily through the haematobronchial barrier. The association of amoxicillin and carbocisteine, determining an increase of the quantitative levels of antibiotic in the bronchial secretion (also if it is purulent), performs a sterilizing action in a short time with significant therapeutic advantages.
| Original language | English |
|---|---|
| Pages (from-to) | 331-340 |
| Number of pages | 10 |
| Journal | International Journal of Clinical Pharmacology Research |
| Volume | 5 |
| Issue number | 5 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Comparison between penetration of amoxicillin combined with carbocisteine and amoxicillin alone in pathological bronchial secretions and pulmonary tissue. / Braga, P. C.; Scaglione, F.; Scarpazza, G.; Fraticelli, G.; Roviaro, G.; Varoli, F.; Mariani, C.; Falchi, M.; Fraschini, F.
In: International Journal of Clinical Pharmacology Research, Vol. 5, No. 5, 1985, p. 331-340.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison between penetration of amoxicillin combined with carbocisteine and amoxicillin alone in pathological bronchial secretions and pulmonary tissue
AU - Braga, P. C.
AU - Scaglione, F.
AU - Scarpazza, G.
AU - Fraticelli, G.
AU - Roviaro, G.
AU - Varoli, F.
AU - Mariani, C.
AU - Falchi, M.
AU - Fraschini, F.
PY - 1985
Y1 - 1985
N2 - Patients with chronic bronchitis were treated orally with either amoxicillin (500 mg) alone or in combination with carbocisteine (150 mg), thrice daily for five days, in order to assess whether the combination allows higher antibiotic levels to be obtained in bronchial mucus than those obtained from amoxicillin alone. Serum and mucus levels were determined for each patient at first and fifth day of the two drug regimens. The levels of amoxicillin in the lung tissue collected in patients undergoing pulmonary surgery were also determined after a single oral dose of amoxicillin (1 g) or of amoxicillin (1 g) plus carbocisteine (300 mg). In the bronchial secretions, at the same plasma concentrations, amoxicillin levels were statistically higher after administration of combined substances. These findings indicate the presence of a pharmacokinetic synergism between these compounds, which allows amoxicillin to penetrate more easily through the haematobronchial barrier. The association of amoxicillin and carbocisteine, determining an increase of the quantitative levels of antibiotic in the bronchial secretion (also if it is purulent), performs a sterilizing action in a short time with significant therapeutic advantages.
AB - Patients with chronic bronchitis were treated orally with either amoxicillin (500 mg) alone or in combination with carbocisteine (150 mg), thrice daily for five days, in order to assess whether the combination allows higher antibiotic levels to be obtained in bronchial mucus than those obtained from amoxicillin alone. Serum and mucus levels were determined for each patient at first and fifth day of the two drug regimens. The levels of amoxicillin in the lung tissue collected in patients undergoing pulmonary surgery were also determined after a single oral dose of amoxicillin (1 g) or of amoxicillin (1 g) plus carbocisteine (300 mg). In the bronchial secretions, at the same plasma concentrations, amoxicillin levels were statistically higher after administration of combined substances. These findings indicate the presence of a pharmacokinetic synergism between these compounds, which allows amoxicillin to penetrate more easily through the haematobronchial barrier. The association of amoxicillin and carbocisteine, determining an increase of the quantitative levels of antibiotic in the bronchial secretion (also if it is purulent), performs a sterilizing action in a short time with significant therapeutic advantages.
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M3 - Article
C2 - 4066083
AN - SCOPUS:0022351230
VL - 5
SP - 331
EP - 340
JO - International Journal of Clinical Pharmacology Research
JF - International Journal of Clinical Pharmacology Research
SN - 0251-1649
IS - 5
ER -