Comparison between rules-based human immunodeficiency virus type 1 genotype interpretations and real or virtual phenotype: Concordance analysis and correlation with clinical outcome in heavily treated patients

Carlo Torti, Eugenia Quiros-Roldan, Wilco Keulen, Luigia Scudeller, Sergio Lo Caputo, Charles Boucher, Francesco Castelli, Francesco Mazzotta, Piera Pierotti, Anne Mieke Been-Tiktak, Giovanni Buccoliero, Michele De Gennaro, Giampiero Carosi, Carmine Tinelli

Research output: Contribution to journalArticlepeer-review

Abstract

We compared 2 rules-based genotype interpretation systems and real or virtual phenotype through a retrospective analysis of a prospective trial. Genotypes were determined with VircoGEN II (VIRCO) and were interpreted with either RetroGram 1.4 or TRUGENE HIV-1 (guidelines 3.0) or original virtual phenotype (Virtual Phenotype; VIRCO), as available in the year 2000. Among 188 human immunodeficiency virus (HIV) type 1 isolates, overall concordance (κ agreement) was observed for the 2 rules-based systems, whereas striking discordances were noted between them and real and virtual phenotype interpretations for stavudine, didanosine, zalcitabine, abacavir, and amprenavir (κ > 0.4). Clinical evaluation of a subset of 173 patients showed that both rules-based sensitivity scores were independently associated with HIV RNA loads

Original languageEnglish
Pages (from-to)194-201
Number of pages8
JournalJournal of Infectious Diseases
Volume188
Issue number2
DOIs
Publication statusPublished - Jul 15 2003

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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