Comparison between the antidepressant activity of S-adenosylmethionine (SAMe) and that of some tricyclic drugs

L. Miccoli, V. Porro, A. Bertolino

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Two groups of patients with depressive syndromes according to Kielholz's classification were treated daily with intravenous doses of 200 mg SAMe and 100 mg of tricyclic antidepressants such as chloroimipramine or amitriptyline, respectively, over a period of 21 days. Therapeutic effects were observed after 7 and 21 days. SAMe has been shown to exert an anti-depressive action comparable to that of chloroimipramine and amitriptyline, yet with a remarkably more rapid effect and no significant side-effects.

Original languageEnglish
Pages (from-to)243-255
Number of pages13
JournalActa Neurologica
Issue number3
Publication statusPublished - 1978


ASJC Scopus subject areas

  • Clinical Neurology

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