Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: The HYPER Study

Rocco Maurizio Zagari, Gabriele Bianchi-Porro, Roberto Fiocca, Giovanni Gasbarrini, Enrico Roda, Franco Bazzoli

Research output: Contribution to journalArticle

Abstract

Background: Triple therapy is recommended for Helicobacter pylori eradication, yet consensus on the duration of treatment is lacking. Aim: To compare the efficacy and safely of 1- and 2-week regimens of omeprazole, amoxicillin and clarithromycin in a large, multicentre, double-blind and randomised study. Methods: A total of 909 H pylori-positive patients with duodenal ulcer, enrolled in 81 endoscopy units in Italy, were randomised to receive omeprazole, amoxicillin and clarithromycin for either 1 week (OAC1W) or 2 weeks (OAC2W) or omeprazole and amoxicillin for 2 weeks. H pylori eradication was assessed by histological examination and carbon-13 urea breath test 4 weeks after treatment. Results: Both the intention-to-treat (ITT; n = 907) and per protocol (PP; n = 661) analyses showed no significant differences between the eradication rates of OAC1W (ITT 79.7%; PP 83.6%) and OAC2W (ITT 81.7%; PP 84.9%; ITT p = 0.53; PP p = 0.71). Both triple omeprazole, amoxicillin and clarithromycin regimens gave significantly higher eradication rates compared with omeprazole and amoxicillin treatment (ITT 44.6%; PP 42.8%; p

Original languageEnglish
Pages (from-to)475-479
Number of pages5
JournalGut
Volume56
Issue number4
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Gastroenterology

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