Comparison of 24-h volume and creatinine-corrected total urinary polyphenol as a biomarker of total dietary polyphenols in the Invecchiare InCHIANTI study

Raul Zamora-Ros, Montserrat Rabassa, Antonio Cherubini, Mireia Urpi-Sarda, Rafael Llorach, Stefania Bandinelli, Luigi Ferrucci, Cristina Andres-Lacueva

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Polyphenols have beneficial effects on several chronic diseases but assessing polyphenols intake from self-reported dietary questionnaires tends to be inaccurate and not very reliable. A promising alternative is to use urinary excretion of polyphenols as a proxy measure of intake. The best method to assess urinary excretion is to collect 24-h urine. However, since collecting 24-h urine method is expensive, time consuming and may be difficult to implement in large population-based studies, measures obtained from spot urine normalized by creatinine are commonly used. The purpose of the study was to evaluate the correlation between polyphenols dietary intake and total urinary polyphenol excretion (TPE), expressed by both 24-h volume and urinary creatinine normalization in 928 participants from the InCHIANTI study. Dietary intake data were collected using a validated food frequency questionnaire. Urinary TPE was analyzed by Folin-Ciocalteau assay. Both urinary TPE expression models were statistically correlated (r= 0.580), and the partial correlation coefficient improved (pr = 0.722) after adjusting for the variables that modify the urinary creatinine excretion (i.e. gender, age, BMI, physical activity and renal function). In crude models, polyphenol intake was associated with TPE corrected by 24-h volume (r= 0.211; P

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalAnalytica Chimica Acta
Volume704
Issue number1-2
DOIs
Publication statusPublished - Oct 17 2011

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Polyphenols
Biomarkers
excretion
biomarker
Creatinine
urine
Urine
physical activity
comparison
Proxy
gender
assay
Assays
Chronic Disease
food
Exercise
Kidney
Food

Keywords

  • Biomarker
  • Creatinine normalization
  • InCHIANTI study
  • Polyphenols
  • Urine 24-h

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Comparison of 24-h volume and creatinine-corrected total urinary polyphenol as a biomarker of total dietary polyphenols in the Invecchiare InCHIANTI study. / Zamora-Ros, Raul; Rabassa, Montserrat; Cherubini, Antonio; Urpi-Sarda, Mireia; Llorach, Rafael; Bandinelli, Stefania; Ferrucci, Luigi; Andres-Lacueva, Cristina.

In: Analytica Chimica Acta, Vol. 704, No. 1-2, 17.10.2011, p. 110-115.

Research output: Contribution to journalArticle

Zamora-Ros, Raul ; Rabassa, Montserrat ; Cherubini, Antonio ; Urpi-Sarda, Mireia ; Llorach, Rafael ; Bandinelli, Stefania ; Ferrucci, Luigi ; Andres-Lacueva, Cristina. / Comparison of 24-h volume and creatinine-corrected total urinary polyphenol as a biomarker of total dietary polyphenols in the Invecchiare InCHIANTI study. In: Analytica Chimica Acta. 2011 ; Vol. 704, No. 1-2. pp. 110-115.
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