Comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: A european multicentre study

Ettore Ambrosioni, Willem Birkenhäqer, Peter W. De Leeuw, Cesare Dal Palù, Jean Claude Demanet, Gisela Groothold, Arnaldo Libretti, Federico Mailland, Ettore Malacco, Aldo Poli, Edward B. Raftery, John L. Reid, Klaus O. Stumpe, Alberto Zanchetti

Research output: Contribution to journalArticle

Abstract

The therapeutic effectiveness and safety of indenolol, a vasodilating β-blockerwith β2-agonism, was compared with that of atenolol, a cardioselective β-blocker, in a 1-year doubl eblindtrial. A total of 143 hypertensive patients (diastolic blood pressure 95-115mmHg after 1 month of placebo) were randomly allocated to either atenolol, 50 mg/day, or indenolol, 60 mg/day. If the target diastolic blood pressure (=S:90mmHg) was not reached after 1 month, the β- blocker was doubled. If the target was still not reached, a diuretic was added after 2 months and doubled after 4 months. There was a higher overall responsiveness and monotherapy was more effective in the atenolol group, but at the lower dose indenolol was more effective than atenolol; however, no differences between drugs were significant. Although the drop-out rate was higher with indenolol, withdrawals due to side effects were similar in both groups. Indenolol was as effective and safe as atenolol in longterm ant ihypertensive therapy.

Original languageEnglish
Pages (from-to)S266-S267
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Keywords

  • Atenolol
  • Hypertension
  • Indenolol

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

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    Ambrosioni, E., Birkenhäqer, W., De Leeuw, P. W., Palù, C. D., Demanet, J. C., Groothold, G., Libretti, A., Mailland, F., Malacco, E., Poli, A., Raftery, E. B., Reid, J. L., Stumpe, K. O., & Zanchetti, A. (1989). Comparison of a vasodilating beta-blocker and a cardioselective beta-blocker in long-term treatment of hypertension: A european multicentre study. Journal of Hypertension, Supplement, 7, S266-S267.