Comparison of an enzyme immunoassay and a latex agglutination system for the diagnosis of invasive aspergillosis in bone marrow transplant recipients

M. Machetti, M. Feasi, N. Mordini, M. T. Van Lint, A. Bacigalupo, J. P. Latgé, J. Sarfati, L. Viscoli

Research output: Contribution to journalArticlepeer-review

Abstract

The performance of two Aspergillus antigenemia systems, the sandwich enzyme-linked immunosorbent assay (ELISA), Platelia Aspergillus test, and the latex agglutination (LA), Pastorex Aspergillus test, in the diagnosis of invasive aspergillosis were compared by testing 364 serum samples from 22 bone marrow transplant (BMT) recipients. Sensitivity and specificity for the ELISA test were 60% and 82% respectively, vs 40% and 94% for the LA test. In the two patients found positive with both methods, the ELISA test became positive earlier than the LA test or remained positive after the LA test had become negative. These results encourage further evaluation of the Platelia Aspergillus test, to assess its role in the management of invasive aspergillosis in BMT patients.

Original languageEnglish
Pages (from-to)917-921
Number of pages5
JournalBone Marrow Transplantation
Volume21
Issue number9
Publication statusPublished - May 1 1998

Keywords

  • Antigen detection
  • Galactomannan
  • Invasive aspergillosis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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