Comparison of androgen receptor, vegf, hif-1, ki67 and mmp9 expression between non-metastatic and metastatic stages in stromal and tumor cells of oral squamous cell carcinoma

Lovorka Batelja-Vuletic, Cedna Tomasovic-Loncaric, Marcello Ceppi, Marco Bruzzone, Aleksandra Fucic, Karolina Krstanac, Vanja Boras Vucicevic

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral malignancy with low survival as it is very often diagnosed at an advanced stage, which is why the accurate profiling of the tumor is essential. The aim of this study was to, for the first time, compare in OSCC the frequency of AR, VEGF, MMP9, HiF1beta and Ki67 between the non-metastatic and metastatic disease. Materials and Methods: In the study, 96 non-metastatic and 91 metastatic OSCC patients were analysed for AR, VEGF, MMP9, HiF1beta and Ki67 levels by immunohistochemistry. Results: All of the tested biomarkers significantly differed between non-metastatic and metastatic disease. A significant association was found between >/=20% AR positive epithelium cells in cytoplasm, Ki67 and VEGF in cancer stroma. Ki67, HiF1beta, VEGF and MMP9 were significantly associated with TNM stages. Conclusion: Our results show for the first time an interplay between AR, VEGF, MMP9, HiF1beta and Ki67 in OSCC which may contribute to better diagnostics and therapy selection.

Original languageEnglish
Article number336
JournalLife
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2021

Keywords

  • Androgen receptor
  • HIF-1
  • Ki67
  • MMP9
  • Oral squamous cell carcinoma
  • VEGF

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Space and Planetary Science
  • Palaeontology

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