Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI)

Henri J.M.M. Mutsaerts, Jan Petr, David L. Thomas, Enrico De Vita, David M. Cash, Matthias J.P. van Osch, Xavier Golay, Paul F.C. Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B. Rowe, Caroline Graff, Francesca B. Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo BrancoJonathan D. Rohrer, Mario Masellis, Bradley J. MacIntosh, Martin Rossor, Nick Fox, Jason Warren, Martina Bocchetta, Katrina Dick, Michela Pievani, Roberta Ghidoni, Luisa Benussi, Alessandro Padovani, Maura Cosseddu, Alexandre Mendonça, Giovanni Frisoni, Enrico Premi, Silvana Archetti, Elio Scarpini, Giorgio Fumagalli, Andrea Arighi, Chiara Fenoglio, Sara Prioni, Veronica Redaelii, Marina Grisoli, Pietro Tiraboschi, Sandra Black, Ekaterina Rogaeva, Morris Freedman, Maria Carmela Tartaglia, David Tang-Wai, on behalf of the GENFI investigators

Research output: Contribution to journalArticle

Abstract

Purpose: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. Materials and Methods: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking). In addition to visual comparison, we quantified image similarity using the Pearson correlation coefficient (CC), and used the Mann-Whitney U rank sum test. Results: CBF-pGM outperformed M0-T1w (CC improvement 47.2% ± 22.0%; P < 0.001), and the non-rigid transformation outperformed rigid-body (20.6% ± 5.3%; P < 0.001). Masking only improved the M0-T1w rigid-body registration (14.5% ± 15.5%; P = 0.007). Conclusion: The choice of image registration strategy impacts ASL group analyses. The non-rigid transformation is promising but requires validation. CBF-pGM rigid-body registration without masking can be used as a default strategy. In patients with expansive perfusion deficits, M0-T1w may outperform CBF-pGM in sequences with high effective spatial resolution. BET-masking only improves M0-T1w registration when the M0 image has sufficient contrast. Level of Evidence: 1. Technical Efficacy: Stage 1. J. Magn. Reson. Imaging 2018;47:131–140.

Original languageEnglish
Pages (from-to)131-140
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume47
Issue number1
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • arterial spin labeling
  • cerebral blood flow
  • image registration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Mutsaerts, H. J. M. M., Petr, J., Thomas, D. L., De Vita, E., Cash, D. M., van Osch, M. J. P., Golay, X., Groot, P. F. C., Ourselin, S., van Swieten, J., Laforce, R., Tagliavini, F., Borroni, B., Galimberti, D., Rowe, J. B., Graff, C., Pizzini, F. B., Finger, E., Sorbi, S., ... on behalf of the GENFI investigators (2018). Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). Journal of Magnetic Resonance Imaging, 47(1), 131-140. https://doi.org/10.1002/jmri.25751