Abstract
In the present study we evaluated plasma levels of two markers of bone turnover (osteocalcin (OC) and urinary pyridinium cross-links) in association with bone mineral density (BMI) in different groups of climacteric women. We have investigated 158 women in pre-, peri,- and postmenopause. Blood and urine samples for assay of hormones and markers were collected and bone mineral density (BMD) was measured by DEXA densitometry in the distal tenth of the non-dominant forearm. There was a significant increase in mean absolute levels of both markers in perimenopause and women in natural and surgical menopause, with respect to women in premenopause. There was a significant correlation between OC and deoxypyridoline (DPYR) in peri- and postmenopause groups. In peri- and postmenopause groups, BMD was correlated with an increase in the biochemical markers of bone remodeling. In the present study, OC and DPYR were found to have good sensitivity for identifying perimenopausal women with pathological BMD. The present results reveal a positive and significant correlation between DPYR and OC, inversely proportional to BMD, during hormone replacement therapy. These markers therefore turn out to be sensitive not only for monitoring severe pathology of bone turnover, but also for monitoring slight physiological deficits in bone equilibrium beginning in perimenopause.
| Original language | English |
|---|---|
| Pages (from-to) | 466-471 |
| Number of pages | 6 |
| Journal | Gynecological Endocrinology |
| Volume | 15 |
| Issue number | 6 |
| Publication status | Published - 2001 |
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Keywords
- Bone Mineral Density
- Hormone Replacement Therapy
- Osteocalcin
- Osteoporosis
- Urinary Pyridinium Cross-links
ASJC Scopus subject areas
- Endocrinology
- Obstetrics and Gynaecology
Cite this
Comparison of biochemical markers of bone turnover and bone mineral density in different groups of climacteric women. / Morgante, G.; La Marca, A.; Ditto, A.; Musacchio, M. C.; Cavicchioli, C.; Lanzetta, D.; Petraglia, F.; De Leo, V.
In: Gynecological Endocrinology, Vol. 15, No. 6, 2001, p. 466-471.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of biochemical markers of bone turnover and bone mineral density in different groups of climacteric women
AU - Morgante, G.
AU - La Marca, A.
AU - Ditto, A.
AU - Musacchio, M. C.
AU - Cavicchioli, C.
AU - Lanzetta, D.
AU - Petraglia, F.
AU - De Leo, V.
PY - 2001
Y1 - 2001
N2 - In the present study we evaluated plasma levels of two markers of bone turnover (osteocalcin (OC) and urinary pyridinium cross-links) in association with bone mineral density (BMI) in different groups of climacteric women. We have investigated 158 women in pre-, peri,- and postmenopause. Blood and urine samples for assay of hormones and markers were collected and bone mineral density (BMD) was measured by DEXA densitometry in the distal tenth of the non-dominant forearm. There was a significant increase in mean absolute levels of both markers in perimenopause and women in natural and surgical menopause, with respect to women in premenopause. There was a significant correlation between OC and deoxypyridoline (DPYR) in peri- and postmenopause groups. In peri- and postmenopause groups, BMD was correlated with an increase in the biochemical markers of bone remodeling. In the present study, OC and DPYR were found to have good sensitivity for identifying perimenopausal women with pathological BMD. The present results reveal a positive and significant correlation between DPYR and OC, inversely proportional to BMD, during hormone replacement therapy. These markers therefore turn out to be sensitive not only for monitoring severe pathology of bone turnover, but also for monitoring slight physiological deficits in bone equilibrium beginning in perimenopause.
AB - In the present study we evaluated plasma levels of two markers of bone turnover (osteocalcin (OC) and urinary pyridinium cross-links) in association with bone mineral density (BMI) in different groups of climacteric women. We have investigated 158 women in pre-, peri,- and postmenopause. Blood and urine samples for assay of hormones and markers were collected and bone mineral density (BMD) was measured by DEXA densitometry in the distal tenth of the non-dominant forearm. There was a significant increase in mean absolute levels of both markers in perimenopause and women in natural and surgical menopause, with respect to women in premenopause. There was a significant correlation between OC and deoxypyridoline (DPYR) in peri- and postmenopause groups. In peri- and postmenopause groups, BMD was correlated with an increase in the biochemical markers of bone remodeling. In the present study, OC and DPYR were found to have good sensitivity for identifying perimenopausal women with pathological BMD. The present results reveal a positive and significant correlation between DPYR and OC, inversely proportional to BMD, during hormone replacement therapy. These markers therefore turn out to be sensitive not only for monitoring severe pathology of bone turnover, but also for monitoring slight physiological deficits in bone equilibrium beginning in perimenopause.
KW - Bone Mineral Density
KW - Hormone Replacement Therapy
KW - Osteocalcin
KW - Osteoporosis
KW - Urinary Pyridinium Cross-links
UR - http://www.scopus.com/inward/record.url?scp=0035702394&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035702394&partnerID=8YFLogxK
M3 - Article
C2 - 11826771
AN - SCOPUS:0035702394
VL - 15
SP - 466
EP - 471
JO - Gynecological Endocrinology
JF - Gynecological Endocrinology
SN - 0951-3590
IS - 6
ER -