TY - JOUR
T1 - Comparison of Brain Natriuretic Peptide Plasma Levels Versus Logistic EuroSCORE in Predicting In-Hospital and Late Postoperative Mortality in Patients Undergoing Aortic Valve Replacement for Symptomatic Aortic Stenosis
AU - Pedrazzini, Giovanni Battista
AU - Masson, Serge
AU - Latini, Roberto
AU - Klersy, Catherine
AU - Rossi, Maria Grazia
AU - Pasotti, Elena
AU - Faletra, Francesco Fulvio
AU - Siclari, Francesco
AU - Minervini, Fabrizio
AU - Moccetti, Tiziano
AU - Auricchio, Angelo
PY - 2008/9/15
Y1 - 2008/9/15
N2 - The accuracy of the logistic EuroSCORE (logES), a widely used risk prediction algorithm for cardiac surgery including aortic valve surgery, usually overestimates observed perioperative mortality. Elevated brain natriuretic peptide (BNP) in symptomatic patients with aortic stenosis (AS) is associated with a poor short-term outcome after aortic valve replacement. We aimed to compare BNP with the logES for predicting short- and long-term outcome in symptomatic patients with severe AS undergoing aortic valve replacement. We prospectively studied 144 consecutive patients referred for aortic valve replacement (42% women, 73 ± 9 years, mean aortic gradient 51 ± 18 mm Hg, and left ventricular ejection fraction 61 ± 11%) undergoing either isolated aortic valve replacement (58%) or combined to bypass grafting. Both plasma BNP and logES was estimated before surgery. The median BNP plasma level and logES were 157 pg/ml (interquartile range [IQR] 61 to 440) and 6.6% (IQR 4.2 to 12.2), respectively. The perioperative mortality was 6% and the overall mortality by the end of the study was 13%. Patients with logES >10.1% (upper tertile) had a higher risk of dying over time (hazard ratio [HR] 2.86, p = 0.037), as had patients with BNP >312 pg/ml (HR 9.01, p
AB - The accuracy of the logistic EuroSCORE (logES), a widely used risk prediction algorithm for cardiac surgery including aortic valve surgery, usually overestimates observed perioperative mortality. Elevated brain natriuretic peptide (BNP) in symptomatic patients with aortic stenosis (AS) is associated with a poor short-term outcome after aortic valve replacement. We aimed to compare BNP with the logES for predicting short- and long-term outcome in symptomatic patients with severe AS undergoing aortic valve replacement. We prospectively studied 144 consecutive patients referred for aortic valve replacement (42% women, 73 ± 9 years, mean aortic gradient 51 ± 18 mm Hg, and left ventricular ejection fraction 61 ± 11%) undergoing either isolated aortic valve replacement (58%) or combined to bypass grafting. Both plasma BNP and logES was estimated before surgery. The median BNP plasma level and logES were 157 pg/ml (interquartile range [IQR] 61 to 440) and 6.6% (IQR 4.2 to 12.2), respectively. The perioperative mortality was 6% and the overall mortality by the end of the study was 13%. Patients with logES >10.1% (upper tertile) had a higher risk of dying over time (hazard ratio [HR] 2.86, p = 0.037), as had patients with BNP >312 pg/ml (HR 9.01, p
UR - http://www.scopus.com/inward/record.url?scp=50949122702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50949122702&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2008.04.055
DO - 10.1016/j.amjcard.2008.04.055
M3 - Article
C2 - 18774001
AN - SCOPUS:50949122702
VL - 102
SP - 749
EP - 754
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 6
ER -