Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome

Arthur J. Moss, Jennifer L. Robinson, Laura Gessman, Robert Gillespie, Wojciech Zareba, Peter J. Schwartz, G. Michael Vincent, Jesaia Benhorin, Emanuela Locati Heilbron, Jeffrey A. Towbin, Silvia G. Priori, Carlo Napolitano, Li Zhang, Aharon Medina, Mark L. Andrews, Katherine Timothy

Research output: Contribution to journalArticlepeer-review

Abstract

Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS). We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident. Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p

Original languageEnglish
Pages (from-to)876-879
Number of pages4
JournalThe American Journal of Cardiology
Volume84
Issue number8
DOIs
Publication statusPublished - Oct 15 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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