Comparison of combined therapies in treatment of secondary failure to glyburide

V. Trischitta, S. Italia, S. Mazzarino, M. Buscema, A. M. Rabuazzo, L. Sangiorgio, S. Squatrito, R. Vigneri

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE - To compare the effectiveness of alternative combined treatments in patients with non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure to sulfonylureas. RESEARCH DESIGN AND METHODS - A crossover study was carried out by randomly assigning 16 NIDDM patients to a combined treatment with the addition of either a single low-dose bedtime injection of 0.2 U/kg body wt NPH insulin or an oral three times a day administration of 1.5 g/day metformin to the previously ineffective glyburide treatment. RESULTS - Both combined therapies significantly (P <0.01) reduced fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and percentage of HbA1. The addition of metformin was more effective than the addition of insulin (P <0.01) in improving PPPG in the 8 patients with higher postglucagon C-peptide levels. In contrast, the efficacy of neither combined therapy was related to patient age, age of diabetes onset, duration of the disease, percentage of ideal body weight, and FPG. The addition of insulin but not metformin caused a significant (P <0.01) increase of mean body weight. Neither combined treatment caused changes in serum cholesterol and trygliceride levels. No symptomatic hypoglycemic episode was reported in any of the 16 patients. CONCLUSIONS - The addition of bedtime NPH insulin or metformin was effective in improving the glycemic control in most NIDDM patients with secondary failure to glyburide. The combination of metformin and sulfonylurea was more effective in reducing PPPG and did not induce any increase of body weight.

Original languageEnglish
Pages (from-to)539-542
Number of pages4
JournalDiabetes Care
Volume15
Issue number4
Publication statusPublished - 1992

Fingerprint

Glyburide
Treatment Failure
Metformin
Glucose
Isophane Insulin
Type 2 Diabetes Mellitus
Fasting
Therapeutics
Body Weight
Insulin
Ideal Body Weight
C-Peptide
Glycosylated Hemoglobin A
Age of Onset
Hypoglycemic Agents
Cross-Over Studies
Research Design
Cholesterol
Injections
Serum

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Trischitta, V., Italia, S., Mazzarino, S., Buscema, M., Rabuazzo, A. M., Sangiorgio, L., ... Vigneri, R. (1992). Comparison of combined therapies in treatment of secondary failure to glyburide. Diabetes Care, 15(4), 539-542.

Comparison of combined therapies in treatment of secondary failure to glyburide. / Trischitta, V.; Italia, S.; Mazzarino, S.; Buscema, M.; Rabuazzo, A. M.; Sangiorgio, L.; Squatrito, S.; Vigneri, R.

In: Diabetes Care, Vol. 15, No. 4, 1992, p. 539-542.

Research output: Contribution to journalArticle

Trischitta, V, Italia, S, Mazzarino, S, Buscema, M, Rabuazzo, AM, Sangiorgio, L, Squatrito, S & Vigneri, R 1992, 'Comparison of combined therapies in treatment of secondary failure to glyburide', Diabetes Care, vol. 15, no. 4, pp. 539-542.
Trischitta V, Italia S, Mazzarino S, Buscema M, Rabuazzo AM, Sangiorgio L et al. Comparison of combined therapies in treatment of secondary failure to glyburide. Diabetes Care. 1992;15(4):539-542.
Trischitta, V. ; Italia, S. ; Mazzarino, S. ; Buscema, M. ; Rabuazzo, A. M. ; Sangiorgio, L. ; Squatrito, S. ; Vigneri, R. / Comparison of combined therapies in treatment of secondary failure to glyburide. In: Diabetes Care. 1992 ; Vol. 15, No. 4. pp. 539-542.
@article{fd0df5407350486aae6af1f74b693775,
title = "Comparison of combined therapies in treatment of secondary failure to glyburide",
abstract = "OBJECTIVE - To compare the effectiveness of alternative combined treatments in patients with non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure to sulfonylureas. RESEARCH DESIGN AND METHODS - A crossover study was carried out by randomly assigning 16 NIDDM patients to a combined treatment with the addition of either a single low-dose bedtime injection of 0.2 U/kg body wt NPH insulin or an oral three times a day administration of 1.5 g/day metformin to the previously ineffective glyburide treatment. RESULTS - Both combined therapies significantly (P <0.01) reduced fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and percentage of HbA1. The addition of metformin was more effective than the addition of insulin (P <0.01) in improving PPPG in the 8 patients with higher postglucagon C-peptide levels. In contrast, the efficacy of neither combined therapy was related to patient age, age of diabetes onset, duration of the disease, percentage of ideal body weight, and FPG. The addition of insulin but not metformin caused a significant (P <0.01) increase of mean body weight. Neither combined treatment caused changes in serum cholesterol and trygliceride levels. No symptomatic hypoglycemic episode was reported in any of the 16 patients. CONCLUSIONS - The addition of bedtime NPH insulin or metformin was effective in improving the glycemic control in most NIDDM patients with secondary failure to glyburide. The combination of metformin and sulfonylurea was more effective in reducing PPPG and did not induce any increase of body weight.",
author = "V. Trischitta and S. Italia and S. Mazzarino and M. Buscema and Rabuazzo, {A. M.} and L. Sangiorgio and S. Squatrito and R. Vigneri",
year = "1992",
language = "English",
volume = "15",
pages = "539--542",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "4",

}

TY - JOUR

T1 - Comparison of combined therapies in treatment of secondary failure to glyburide

AU - Trischitta, V.

AU - Italia, S.

AU - Mazzarino, S.

AU - Buscema, M.

AU - Rabuazzo, A. M.

AU - Sangiorgio, L.

AU - Squatrito, S.

AU - Vigneri, R.

PY - 1992

Y1 - 1992

N2 - OBJECTIVE - To compare the effectiveness of alternative combined treatments in patients with non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure to sulfonylureas. RESEARCH DESIGN AND METHODS - A crossover study was carried out by randomly assigning 16 NIDDM patients to a combined treatment with the addition of either a single low-dose bedtime injection of 0.2 U/kg body wt NPH insulin or an oral three times a day administration of 1.5 g/day metformin to the previously ineffective glyburide treatment. RESULTS - Both combined therapies significantly (P <0.01) reduced fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and percentage of HbA1. The addition of metformin was more effective than the addition of insulin (P <0.01) in improving PPPG in the 8 patients with higher postglucagon C-peptide levels. In contrast, the efficacy of neither combined therapy was related to patient age, age of diabetes onset, duration of the disease, percentage of ideal body weight, and FPG. The addition of insulin but not metformin caused a significant (P <0.01) increase of mean body weight. Neither combined treatment caused changes in serum cholesterol and trygliceride levels. No symptomatic hypoglycemic episode was reported in any of the 16 patients. CONCLUSIONS - The addition of bedtime NPH insulin or metformin was effective in improving the glycemic control in most NIDDM patients with secondary failure to glyburide. The combination of metformin and sulfonylurea was more effective in reducing PPPG and did not induce any increase of body weight.

AB - OBJECTIVE - To compare the effectiveness of alternative combined treatments in patients with non-insulin-dependent diabetes mellitus (NIDDM) with secondary failure to sulfonylureas. RESEARCH DESIGN AND METHODS - A crossover study was carried out by randomly assigning 16 NIDDM patients to a combined treatment with the addition of either a single low-dose bedtime injection of 0.2 U/kg body wt NPH insulin or an oral three times a day administration of 1.5 g/day metformin to the previously ineffective glyburide treatment. RESULTS - Both combined therapies significantly (P <0.01) reduced fasting plasma glucose (FPG), postprandial plasma glucose (PPPG) and percentage of HbA1. The addition of metformin was more effective than the addition of insulin (P <0.01) in improving PPPG in the 8 patients with higher postglucagon C-peptide levels. In contrast, the efficacy of neither combined therapy was related to patient age, age of diabetes onset, duration of the disease, percentage of ideal body weight, and FPG. The addition of insulin but not metformin caused a significant (P <0.01) increase of mean body weight. Neither combined treatment caused changes in serum cholesterol and trygliceride levels. No symptomatic hypoglycemic episode was reported in any of the 16 patients. CONCLUSIONS - The addition of bedtime NPH insulin or metformin was effective in improving the glycemic control in most NIDDM patients with secondary failure to glyburide. The combination of metformin and sulfonylurea was more effective in reducing PPPG and did not induce any increase of body weight.

UR - http://www.scopus.com/inward/record.url?scp=0026531989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026531989&partnerID=8YFLogxK

M3 - Article

VL - 15

SP - 539

EP - 542

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 4

ER -