Comparison of continuous versus intermittent hepatic pedicle clamping in an experimental model

A. Chiappa, M. Makuuchi, A. P. Zbar, F. Biella, A. Vezzoni, S. Pozzi, B. Andreoni

Research output: Contribution to journalArticlepeer-review


Background/Aims: The tolerance of the liver to ischemia obtained with intermittent clamping of the hepatic pedicle or continuous Pringle maneuver was tested. Methodology: Ninety rats were divided into three groups undergoing total duration of clamping ischemia of 60, 90, and 120min. Each group of rats were subdivided to receive continuous Pringle maneuver, 30-min or 15-min intermittent clamping. The clamp release time between the periods of liver ischemia was 5min. Survival at 7 days and postoperative changes of liver function (transaminase enzymes, bilirubin, and adenosine-5′-triphosphate levels (hepatocellular damage index) were recorded. Results: Intermittent clamping of the hepatic pedicle was better tolerated than the continuous clamping method. With continuous clamping the rat survival rates inversely correlated with the duration of ischemia. Survival rates at 15-min and 30-min intermittent ischemia groups were significantly higher than in the continuous clamping group. Conclusions: This data suggest that when the Pringle maneuver is adopted, it should be applied intermittently rather than continuously.

Original languageEnglish
Pages (from-to)1416-1420
Number of pages5
Issue number41
Publication statusPublished - 2001


  • Energy charge
  • Liver ischemia
  • Liver tissue adenosine 5′-triphosphate

ASJC Scopus subject areas

  • Gastroenterology


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