Comparison of contrast and noncontrast magnetic resonance angiography for quantitative analysis of thoracic arteries in young patients with congenital heart defects

Alessia Del Pasqua, Silvina Barcudi, Benedetta Leonardi, Domenico Clemente, Mauro Colajacomo, Stephen P. Sanders

Research output: Contribution to journalArticlepeer-review

Abstract

Background : Contrast MRA (C-MRA) is the standard for quantitative analysis of thoracic vessels. We evaluated a noncontrast MRA (NC-MRA) sequence (3-D EKG and navigator-gated SSFP) for quantitative evaluation of the thoracic aorta and branch pulmonary arteries in young patients with congenital heart disease. Objective : To compare contrast and noncontrast magnetic resonance angiography for quantitative analysis of thoracic arteries in young patients with congenital heart defects. Methods : Measurements of thoracic aorta and branch pulmonary arteries were obtained from C-MRA and NC-MRA images in 51 patients, ages 2-35 years. Vessel diameters were compared using correlation and Bland-Altman analysis. Interobserver variability was assessed using percent variation. Results : C-MRA and NC-MRA measurements were highly correlated (r = 0.91-0.98) except for the right pulmonary artery (r = 0.74, 0.78). Agreement of measurements was excellent (mean difference -0.07 to -0.53 mm; mean % difference -1.8 to -4.9%) except for the right pulmonary artery which was less good (mean difference 0.73, -1.38 mm; -3, -10%). Interobserver variability ranged from 5% to 8% for aortic and from 10% to 16% for pulmonary artery measures. The worse agreement and greater variability of the pulmonary artery measures appears due to difficulty standardizing the measurements in patients with abnormal and irregular vessels. Conclusion : These data indicate that C-MRA and NC-MRA measures are comparable and could be used interchangeably, avoiding administration of contrast in selected patients.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalAnnals of Pediatric Cardiology
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Aorta
  • congenital heart disease
  • magnetic resonance imaging
  • pulmonary artery

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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