Comparison of conventional and highly-sensitive troponin I measurement in ultra-marathon runners

Giuseppe Lippi; Federico Schena; Gian Luca Salvagno; Cantor Tarperi; Rosalia Aloe; Gian Cesare Guidi

doi:10.1007/s11239-011-0651-0

Comparison of conventional and highly-sensitive troponin I measurement in ultra-marathon runners

Giuseppe Lippi, Federico Schena, Gian Luca Salvagno, Cantor Tarperi, Rosalia Aloe, Gian Cesare Guidi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Cardiac troponins are a mainstay in the diagnostic approach of patients with suspected acute coronary syndrome. Along with other causes of cardiac injury, strenuous aerobic exercise is an important source of troponin leakage from myocardium. Due to recent immunoassays development, there is no information on variation of highly-sensitive (HS) troponin I (TnI) in ultra-marathon runners. We studied 15 healthy trained Caucasian athletes before and immediately after completion of a 60 km, ultramarathon. TnI was measured with both the conventional AccuTnI and the novel HS-AccuTnI immunoassays. At the end of the ultra-marathon the concentration of HS-AccuTnI significantly increased from the baseline value (19.2 ± 4.2 vs. 5.2 ± 0.8 ng/l; P = 0.001). The number of athletes displaying HS-AccuTnI values exceeding the 99th percentile of the reference limit was 2 (13%) pre-exercise, increasing significantly to 12 (80%; P

Original language	English
Pages (from-to)	338-342
Number of pages	5
Journal	Journal of Thrombosis and Thrombolysis
Volume	33
Issue number	4
DOIs	https://doi.org/10.1007/s11239-011-0651-0
Publication status	Published - May 2012

Keywords

Cardiac biomarkers
Marathon
Physical exercise
Sport
Troponin

ASJC Scopus subject areas

Hematology
Cardiology and Cardiovascular Medicine

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title = "Comparison of conventional and highly-sensitive troponin I measurement in ultra-marathon runners",

abstract = "Cardiac troponins are a mainstay in the diagnostic approach of patients with suspected acute coronary syndrome. Along with other causes of cardiac injury, strenuous aerobic exercise is an important source of troponin leakage from myocardium. Due to recent immunoassays development, there is no information on variation of highly-sensitive (HS) troponin I (TnI) in ultra-marathon runners. We studied 15 healthy trained Caucasian athletes before and immediately after completion of a 60 km, ultramarathon. TnI was measured with both the conventional AccuTnI and the novel HS-AccuTnI immunoassays. At the end of the ultra-marathon the concentration of HS-AccuTnI significantly increased from the baseline value (19.2 ± 4.2 vs. 5.2 ± 0.8 ng/l; P = 0.001). The number of athletes displaying HS-AccuTnI values exceeding the 99th percentile of the reference limit was 2 (13%) pre-exercise, increasing significantly to 12 (80%; P",

keywords = "Cardiac biomarkers, Marathon, Physical exercise, Sport, Troponin",

author = "Giuseppe Lippi and Federico Schena and Salvagno, {Gian Luca} and Cantor Tarperi and Rosalia Aloe and Guidi, {Gian Cesare}",

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AU - Schena, Federico

AU - Salvagno, Gian Luca

AU - Tarperi, Cantor

AU - Aloe, Rosalia

AU - Guidi, Gian Cesare

PY - 2012/5

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N2 - Cardiac troponins are a mainstay in the diagnostic approach of patients with suspected acute coronary syndrome. Along with other causes of cardiac injury, strenuous aerobic exercise is an important source of troponin leakage from myocardium. Due to recent immunoassays development, there is no information on variation of highly-sensitive (HS) troponin I (TnI) in ultra-marathon runners. We studied 15 healthy trained Caucasian athletes before and immediately after completion of a 60 km, ultramarathon. TnI was measured with both the conventional AccuTnI and the novel HS-AccuTnI immunoassays. At the end of the ultra-marathon the concentration of HS-AccuTnI significantly increased from the baseline value (19.2 ± 4.2 vs. 5.2 ± 0.8 ng/l; P = 0.001). The number of athletes displaying HS-AccuTnI values exceeding the 99th percentile of the reference limit was 2 (13%) pre-exercise, increasing significantly to 12 (80%; P

AB - Cardiac troponins are a mainstay in the diagnostic approach of patients with suspected acute coronary syndrome. Along with other causes of cardiac injury, strenuous aerobic exercise is an important source of troponin leakage from myocardium. Due to recent immunoassays development, there is no information on variation of highly-sensitive (HS) troponin I (TnI) in ultra-marathon runners. We studied 15 healthy trained Caucasian athletes before and immediately after completion of a 60 km, ultramarathon. TnI was measured with both the conventional AccuTnI and the novel HS-AccuTnI immunoassays. At the end of the ultra-marathon the concentration of HS-AccuTnI significantly increased from the baseline value (19.2 ± 4.2 vs. 5.2 ± 0.8 ng/l; P = 0.001). The number of athletes displaying HS-AccuTnI values exceeding the 99th percentile of the reference limit was 2 (13%) pre-exercise, increasing significantly to 12 (80%; P

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