Comparison of conventional and highly-sensitive troponin I measurement in ultra-marathon runners

Giuseppe Lippi, Federico Schena, Gian Luca Salvagno, Cantor Tarperi, Rosalia Aloe, Gian Cesare Guidi

Research output: Contribution to journalArticlepeer-review


Cardiac troponins are a mainstay in the diagnostic approach of patients with suspected acute coronary syndrome. Along with other causes of cardiac injury, strenuous aerobic exercise is an important source of troponin leakage from myocardium. Due to recent immunoassays development, there is no information on variation of highly-sensitive (HS) troponin I (TnI) in ultra-marathon runners. We studied 15 healthy trained Caucasian athletes before and immediately after completion of a 60 km, ultramarathon. TnI was measured with both the conventional AccuTnI and the novel HS-AccuTnI immunoassays. At the end of the ultra-marathon the concentration of HS-AccuTnI significantly increased from the baseline value (19.2 ± 4.2 vs. 5.2 ± 0.8 ng/l; P = 0.001). The number of athletes displaying HS-AccuTnI values exceeding the 99th percentile of the reference limit was 2 (13%) pre-exercise, increasing significantly to 12 (80%; P

Original languageEnglish
Pages (from-to)338-342
Number of pages5
JournalJournal of Thrombosis and Thrombolysis
Issue number4
Publication statusPublished - May 2012


  • Cardiac biomarkers
  • Marathon
  • Physical exercise
  • Sport
  • Troponin

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine


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