Comparison of coronary vasomotor responses to nifedipine in syndrome X and in Prinzmetal's angina pectoris

Piero Montorsi, Margherita Manfredi, Alessandro Loaldi, Franco Fabbiocchi, Alvise Polese, Nicoletta de Cesare, Antonio Bartorelli, Maurizio D. Guazzi

Research output: Contribution to journalArticle

Abstract

To test whether calcium channel blockade plays a similar role in the coronary vasomotion of patients with syndrome X (n = 29) and patients with Prinzmetal's angina pectoris (n = 12), quantitative angiography was used to evaluate the effect of nifedipine (10 mg, sublingually) on the lumen diameter of proximal, mid and distal thirds of normal epicardial branches. The main differences in the coronary vasomotor reaction were uniform vasodilatation in Prinzmetal's angina and a variable response to syndrome X, and a greater increase in the coronary lumen in patients with Prinzmetal's angina as compared with those with syndrome X who showed vasodilatation. The variable response in syndrome X was not related to changes in diastolic pressure and cardiac output. Patients showing coronary constriction were those who responded to nifedipine with a higher degree of tachycardia, which might suggest a neural participation in the paradoxic reaction to this drug. In the Prinzmetal group, on the contrary, at a similar heart rate increase the pattern was invariably vasodilatation. Thus, calcium ions appear to have a different role in the coronary smooth muscle contractility of the 2 series of patients; in fact, in Prinzmetal's angina nifedipine relaxed the coronary arteries to a greater degree and made them unresponsive to stimuli that were still able to cause vasoconstriction in patients with syndrome X.

Original languageEnglish
Pages (from-to)1198-1202
Number of pages5
JournalThe American Journal of Cardiology
Volume63
Issue number17
DOIs
Publication statusPublished - May 15 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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