Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries

U. Baccarani, P. Piselli, D. Serraino, G. L. Adani, D. Lorenzin, M. Gambato, A. Buda, G. Zanus, A. Vitale, A. De Paoli, C. Cimaglia, V. Bresadola, P. Toniutto, A. Risaliti, U. Cillo, F. Bresadola, P. Burra

Research output: Contribution to journalArticle

Abstract

Aim: The purpose of this study is to describe de novo post-liver transplant malignancies and compare their frequency with incidence rates from Italian cancer registries. Patients and methods: Four hundred and seventeen patients subjected to liver transplantation, from 1991 to 2005, surviving for at least 30 days and without a previous diagnosis of cancer (including hepatocellular carcinoma), were evaluated for the development of de novo malignancies excluding non-melanoma skin cancers. Results: During a total follow-up time of 2856 person-years, 43 de novo malignancies were diagnosed in 43 liver transplantation recipients (10.3%). The most common cancers were non-Hodgkin lymphoma (9 cases), cancer of the head and neck (8 cases), Kaposi's sarcoma (6 cases) and esophageal carcinoma (5 cases). The 1, 3, 5 and 10 years estimated survival rates were 69%, 57%, 53% and 42%. Patients with de novo cancers had a lower 10-year survival rate than patients without cancers (58% versus 76%, p = 0.005). The risk of cancer after liver transplantation was nearly 3-fold higher than that of the general population of the same age and sex (95% CI: 1.9-3.6). De novo tumour sites or types with significantly elevated SIR included Kaposi's sarcoma (SIR = 144), non-Hodgkin lymphoma (SIR = 13.8), esophagus (SIR = 23.4), head and neck cancers (SIR = 7) and cervix uteri (SIR = 30.7). Conclusions: Tumours after liver transplantation are associated with lower long-term survival, confirming that cancer is a major cause of late mortality in liver transplantation.

Original languageEnglish
Pages (from-to)55-60
Number of pages6
JournalDigestive and Liver Disease
Volume42
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • De novo tumour
  • Immunosuppression
  • Liver transplantation
  • Tumour after transplantation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Fingerprint Dive into the research topics of 'Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries'. Together they form a unique fingerprint.

  • Cite this

    Baccarani, U., Piselli, P., Serraino, D., Adani, G. L., Lorenzin, D., Gambato, M., Buda, A., Zanus, G., Vitale, A., De Paoli, A., Cimaglia, C., Bresadola, V., Toniutto, P., Risaliti, A., Cillo, U., Bresadola, F., & Burra, P. (2010). Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries. Digestive and Liver Disease, 42(1), 55-60. https://doi.org/10.1016/j.dld.2009.04.017