Comparison of different anthelminthic drug regimens against Mansonella perstans filariasis

Enrico Rino Bregani, Angelo Rovellini, Narassem Mbaïdoum, Maria Giovanna Magnini

Research output: Contribution to journalArticle

Abstract

Mansonella perstans filariasis is widely present in Africa and equatorial America and its pathogenicity has recently been reconsidered. Effective treatment is lacking and there is no consensus on the optimal therapeutic approach. The aim of this study was to compare the effects of different drug regimens on M. perstans infection. Six different anthelminthic therapeutic protocols were undertaken on 165 subjects with M. perstans infection and their effects on microfilariae burden were evaluated. Diethylcarbamazine (DEC) was able to reduce microfilariae density in the majority of cases, but it seldom eliminated infection after a single treatment. Mebendazole appeared to be more active than DEC in eliminating the infection, with a comparable rate of overall responses. Ivermectin and praziquantel showed no modification of microfilariae concentration. Thiabendazole showed a small but significant activity against the infection. Combination treatments (DEC plus mebendazole) resulted in a significantly higher activity than the single drugs.

Original languageEnglish
Pages (from-to)458-463
Number of pages6
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume100
Issue number5
DOIs
Publication statusPublished - May 2006

Keywords

  • Chad
  • Diethylcarbamazine
  • Filariasis
  • Mansonella perstans
  • Mebendazole
  • Thiabendazole

ASJC Scopus subject areas

  • Parasitology
  • Medicine(all)

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