Comparison of different positron emission tomography tracers in patients with recurrent medullary thyroid carcinoma: Our experience and a review of the literature

Giorgio Treglia, Paola Castaldi, Maria Felicia Villani, Germano Perotti, Angelina Filice, Valentina Ambrosini, Nadia Cremonini, Annibale Versari, Stefano Fanti, Alessandro Giordano, Vittoria Rufini

Research output: Contribution to journalArticle

Abstract

Several morphological and functional imaging techniques are usually used to detect residual/recurrent medullary thyroid carcinoma (MTC) with variable results; currently, there is growing interest in positron emission tomography (PET) methodology. Herein, we report our experience of and a literature review about the comparison of different positron emission tomography (PET) tracers in patients with residual/recurrent MTC. 18F-DOPA PET/CT seems to be the most useful imaging method to detect recurrent MTC lesions, performing better than 18F-FDG and 68Ga-somatostatin analogs PET/CT. 18F-FDG may complement 18F-DOPA in patients with aggressive tumors. 68Ga-somatostatin analogs PET/CT may be useful to select patients who could benefit from radioreceptor therapy. The information provided by the various PET tracers reflects different metabolic pathways, and may help to select the most appropriate treatment.

Original languageEnglish
Pages (from-to)385-393
Number of pages9
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Volume194
DOIs
Publication statusPublished - 2013

Fingerprint

Positron-Emission Tomography
Fluorodeoxyglucose F18
Somatostatin
Metabolic Networks and Pathways
Medullary Thyroid cancer
Therapeutics
Neoplasms

Keywords

  • Diagnosis
  • Medullary thyroid carcinoma
  • Neuroendocrine tumors
  • PET/CT
  • Positron emission tomography

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Comparison of different positron emission tomography tracers in patients with recurrent medullary thyroid carcinoma : Our experience and a review of the literature. / Treglia, Giorgio; Castaldi, Paola; Villani, Maria Felicia; Perotti, Germano; Filice, Angelina; Ambrosini, Valentina; Cremonini, Nadia; Versari, Annibale; Fanti, Stefano; Giordano, Alessandro; Rufini, Vittoria.

In: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, Vol. 194, 2013, p. 385-393.

Research output: Contribution to journalArticle

@article{f21b0bf2d6b7403395b9886a11f288bd,
title = "Comparison of different positron emission tomography tracers in patients with recurrent medullary thyroid carcinoma: Our experience and a review of the literature",
abstract = "Several morphological and functional imaging techniques are usually used to detect residual/recurrent medullary thyroid carcinoma (MTC) with variable results; currently, there is growing interest in positron emission tomography (PET) methodology. Herein, we report our experience of and a literature review about the comparison of different positron emission tomography (PET) tracers in patients with residual/recurrent MTC. 18F-DOPA PET/CT seems to be the most useful imaging method to detect recurrent MTC lesions, performing better than 18F-FDG and 68Ga-somatostatin analogs PET/CT. 18F-FDG may complement 18F-DOPA in patients with aggressive tumors. 68Ga-somatostatin analogs PET/CT may be useful to select patients who could benefit from radioreceptor therapy. The information provided by the various PET tracers reflects different metabolic pathways, and may help to select the most appropriate treatment.",
keywords = "Diagnosis, Medullary thyroid carcinoma, Neuroendocrine tumors, PET/CT, Positron emission tomography",
author = "Giorgio Treglia and Paola Castaldi and Villani, {Maria Felicia} and Germano Perotti and Angelina Filice and Valentina Ambrosini and Nadia Cremonini and Annibale Versari and Stefano Fanti and Alessandro Giordano and Vittoria Rufini",
year = "2013",
doi = "10.1007/978-3-642-27994-2-21",
language = "English",
volume = "194",
pages = "385--393",
journal = "Recent Results in Cancer Research",
issn = "0080-0015",
publisher = "Springer New York",

}

TY - JOUR

T1 - Comparison of different positron emission tomography tracers in patients with recurrent medullary thyroid carcinoma

T2 - Our experience and a review of the literature

AU - Treglia, Giorgio

AU - Castaldi, Paola

AU - Villani, Maria Felicia

AU - Perotti, Germano

AU - Filice, Angelina

AU - Ambrosini, Valentina

AU - Cremonini, Nadia

AU - Versari, Annibale

AU - Fanti, Stefano

AU - Giordano, Alessandro

AU - Rufini, Vittoria

PY - 2013

Y1 - 2013

N2 - Several morphological and functional imaging techniques are usually used to detect residual/recurrent medullary thyroid carcinoma (MTC) with variable results; currently, there is growing interest in positron emission tomography (PET) methodology. Herein, we report our experience of and a literature review about the comparison of different positron emission tomography (PET) tracers in patients with residual/recurrent MTC. 18F-DOPA PET/CT seems to be the most useful imaging method to detect recurrent MTC lesions, performing better than 18F-FDG and 68Ga-somatostatin analogs PET/CT. 18F-FDG may complement 18F-DOPA in patients with aggressive tumors. 68Ga-somatostatin analogs PET/CT may be useful to select patients who could benefit from radioreceptor therapy. The information provided by the various PET tracers reflects different metabolic pathways, and may help to select the most appropriate treatment.

AB - Several morphological and functional imaging techniques are usually used to detect residual/recurrent medullary thyroid carcinoma (MTC) with variable results; currently, there is growing interest in positron emission tomography (PET) methodology. Herein, we report our experience of and a literature review about the comparison of different positron emission tomography (PET) tracers in patients with residual/recurrent MTC. 18F-DOPA PET/CT seems to be the most useful imaging method to detect recurrent MTC lesions, performing better than 18F-FDG and 68Ga-somatostatin analogs PET/CT. 18F-FDG may complement 18F-DOPA in patients with aggressive tumors. 68Ga-somatostatin analogs PET/CT may be useful to select patients who could benefit from radioreceptor therapy. The information provided by the various PET tracers reflects different metabolic pathways, and may help to select the most appropriate treatment.

KW - Diagnosis

KW - Medullary thyroid carcinoma

KW - Neuroendocrine tumors

KW - PET/CT

KW - Positron emission tomography

UR - http://www.scopus.com/inward/record.url?scp=84867049958&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867049958&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-27994-2-21

DO - 10.1007/978-3-642-27994-2-21

M3 - Article

C2 - 22918771

AN - SCOPUS:84867049958

VL - 194

SP - 385

EP - 393

JO - Recent Results in Cancer Research

JF - Recent Results in Cancer Research

SN - 0080-0015

ER -