Comparison of different treatment planning optimization methods for vaginal HDR brachytherapy with multichannel applicators

A reduction of the high doses to the vaginal mucosa is possible

Mauro Carrara, Davide Cusumano, Tommaso Giandini, Chiara Tenconi, Ester Mazzarella, Simone Grisotto, Eleonora Massari, Davide Mazzeo, Annamaria Cerrotta, Brigida Pappalardi, Carlo Fallai, Emanuele Pignoli

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2 Citations (Scopus)

Abstract

Purpose A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. Methods Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. Results The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. Conclusions Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa.

Original languageEnglish
Pages (from-to)58-65
Number of pages8
JournalPhysica Medica
Volume44
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Brachytherapy
planning
Mucous Membrane
dosage
optimization
Catheters
Vaginal Neoplasms
Organs at Risk
Therapeutics
Endometrial Neoplasms
homogeneity
cancer
simulated annealing
organs
proportion

Keywords

  • HDR brachytherapy
  • HIPO
  • IPSA
  • Multichannel applicator
  • Vaginal cancer

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

@article{890fae40f3b140bebeb7b2c8261d0493,
title = "Comparison of different treatment planning optimization methods for vaginal HDR brachytherapy with multichannel applicators: A reduction of the high doses to the vaginal mucosa is possible",
abstract = "Purpose A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. Methods Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. Results The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. Conclusions Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa.",
keywords = "HDR brachytherapy, HIPO, IPSA, Multichannel applicator, Vaginal cancer",
author = "Mauro Carrara and Davide Cusumano and Tommaso Giandini and Chiara Tenconi and Ester Mazzarella and Simone Grisotto and Eleonora Massari and Davide Mazzeo and Annamaria Cerrotta and Brigida Pappalardi and Carlo Fallai and Emanuele Pignoli",
year = "2017",
month = "12",
day = "1",
doi = "10.1016/j.ejmp.2017.11.007",
language = "English",
volume = "44",
pages = "58--65",
journal = "Physica Medica",
issn = "1120-1797",
publisher = "Associazione Italiana di Fisica Medica",

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TY - JOUR

T1 - Comparison of different treatment planning optimization methods for vaginal HDR brachytherapy with multichannel applicators

T2 - A reduction of the high doses to the vaginal mucosa is possible

AU - Carrara, Mauro

AU - Cusumano, Davide

AU - Giandini, Tommaso

AU - Tenconi, Chiara

AU - Mazzarella, Ester

AU - Grisotto, Simone

AU - Massari, Eleonora

AU - Mazzeo, Davide

AU - Cerrotta, Annamaria

AU - Pappalardi, Brigida

AU - Fallai, Carlo

AU - Pignoli, Emanuele

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Purpose A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. Methods Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. Results The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. Conclusions Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa.

AB - Purpose A direct planning approach with multi-channel vaginal cylinders (MVCs) used for HDR brachytherapy of vaginal cancers is particularly challenging. Purpose of this study was to compare the dosimetric performances of different forward and inverse methods used for the optimization of MVC-based vaginal treatments for endometrial cancer, with a particular attention to the definition of strategies useful to limit the high doses to the vaginal mucosa. Methods Twelve postoperative vaginal HDR brachytherapy treatments performed with MVCs were considered. Plans were retrospectively optimized with three different methods: Dose Point Optimization followed by Graphical Optimization (DPO + GrO), Inverse Planning Simulated Annealing with two different class solutions as starting conditions (surflPSA and homogIPSA) and Hybrid Inverse Planning Optimization (HIPO). Several dosimetric parameters related to target coverage, hot spot extensions and sparing of organs at risk were analyzed to evaluate the quality of the achieved treatment plans. Dose homogeneity index (DHI), conformal index (COIN) and a further parameter quantifying the proportion of the central catheter loading with respect to the overall loading (i.e., the central catheter loading index: CCLI) were also quantified. Results The achieved PTV coverage parameters were highly correlated with each other but uncorrelated with the hot spot quantifiers. HomogIPSA and HIPO achieved higher DHIs and CCLIs and lower volumes of high doses than DPO + GrO and surflPSA. Conclusions Within the investigated optimization methods, HIPO and homoglPSA showed the highest dose homogeneity to the target. In particular, homogIPSA resulted also the most effective in reducing hot spots to the vaginal mucosa.

KW - HDR brachytherapy

KW - HIPO

KW - IPSA

KW - Multichannel applicator

KW - Vaginal cancer

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U2 - 10.1016/j.ejmp.2017.11.007

DO - 10.1016/j.ejmp.2017.11.007

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JO - Physica Medica

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