TY - JOUR
T1 - Comparison of dipyridamole-echocardiography test and exercise thallium-201 scanning for diagnosis of coronary artery disease
AU - Picano, E.
AU - Parodi, O.
AU - Lattanzi, F.
AU - Sambucetti, G.
AU - Masini, M.
AU - Marzullo, P.
AU - Distante, A.
AU - L'Abbate, A.
PY - 1989
Y1 - 1989
N2 - Two noninvasive tests to detect and localize coronary stenoses were compared in a fully blinded protocol. Thallium-201 myocardial perfusion imaging during cycloergometer exercise (TET) and high dose dipyridamole-echocardiography test (DET: 2-D echo monitoring with dipyridamole infusion, up to 0.84 mg/kg in 10 min) were performed in 61 patients with chest pain syndrome. Criteria of positivity were: for TET, a reversible defect of perfusion, as quantitatively assessed by the postexercise and redistribution images; for DET, a transient dyssynergy of contraction, absent or of a lesser degree in resting conditions. All patients underwent coronary angiography; 38 had significant coronary artery disease (at least one major artery with > 70% luminal diameter narrowing). The sensitivity for detecting angiographically assessed coronary artery disease was 86% for TET and 79% for DET (p = NS); the specificity was, respectively, 56 and 100% (p <0.01). In 27 out of the 30 patients in whom both TET and DET yielded positive responses, the same myocardial region was involved. In conclusion, DET represents a reasonable diagnostic alternative to TET, showing a similar sensitivity and a higher specificity for the detection of angiographically assessed coronary artery disease. DET needs an acceptable acoustic window to be performed: it is however less expensive than TET, requires a much shorter imaging time and can also be performed in patients unable to exercise.
AB - Two noninvasive tests to detect and localize coronary stenoses were compared in a fully blinded protocol. Thallium-201 myocardial perfusion imaging during cycloergometer exercise (TET) and high dose dipyridamole-echocardiography test (DET: 2-D echo monitoring with dipyridamole infusion, up to 0.84 mg/kg in 10 min) were performed in 61 patients with chest pain syndrome. Criteria of positivity were: for TET, a reversible defect of perfusion, as quantitatively assessed by the postexercise and redistribution images; for DET, a transient dyssynergy of contraction, absent or of a lesser degree in resting conditions. All patients underwent coronary angiography; 38 had significant coronary artery disease (at least one major artery with > 70% luminal diameter narrowing). The sensitivity for detecting angiographically assessed coronary artery disease was 86% for TET and 79% for DET (p = NS); the specificity was, respectively, 56 and 100% (p <0.01). In 27 out of the 30 patients in whom both TET and DET yielded positive responses, the same myocardial region was involved. In conclusion, DET represents a reasonable diagnostic alternative to TET, showing a similar sensitivity and a higher specificity for the detection of angiographically assessed coronary artery disease. DET needs an acceptable acoustic window to be performed: it is however less expensive than TET, requires a much shorter imaging time and can also be performed in patients unable to exercise.
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M3 - Article
AN - SCOPUS:0024385653
VL - 3
SP - 85
EP - 92
JO - American Journal of Noninvasive Cardiology
JF - American Journal of Noninvasive Cardiology
SN - 0258-4425
IS - 2-3
ER -