Comparison of fentanyl with clonidine as adjuvants for epidural analgesia with 0.125% bupivacaine in the first stage of labor. A preliminary report

D. Celleno, G. Capogna, P. Costantino, A. Zangrillo

Research output: Contribution to journalArticle


48 primiparae received epidural analgesia in labor with 10 ml of 0.125% bupivacaine with epinephrine 1:800 000, and then were divided in 4 equal groups (n = 12) to receive one of the following: 5 ml saline (B); 100 μg of fentanyl (BF); 150 μg of clonidine (BC); 75 μg of clonidine and 50 μg of fentanyl (BCF). All the patients had satisfactory analgesia. Onset was similar in the 4 groups but the duration of analgesia was significantly prolonged by the addition of either 100 μg of fentanyl or 150 μg of clonidine (respectively 89.8 min and 92.5 min vs 62.5 min) (P <0.0001). The addition of both clonidine (75 μg) and fentanyl (50 μg) produced a considerably prolonged analgesia (177.5 min) (P <0.0001). No episodes of bradycardia were observed. Hypotension, reversed by i.v. ephedrine, occurred in 2 patients of BCF group and in 1 patient of BF and BC groups. Only patients receiving fentanyl had pruritus. Both fentanyl and clonidine produced sedation, but both incidence and severity were greater with the mixture. No differences in neonatal outcome assessed by Apgar scores and NACS, were observed.

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalInternational Journal of Obstetric Anesthesia
Issue number1
Publication statusPublished - 1995


ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Obstetrics and Gynaecology
  • Psychology(all)

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