Comparison of gadobenate dimeglumine-enhanced breast MRI and gadopentetate dimeglumine-enhanced breast MRI with mammography and ultrasound for the detection of breast cancer

Fiona J. Gilbert, Harrie C M Van Den Bosch, Antonella Petrillo, Katja Siegmann, Johannes T. Heverhagen, Pietro Panizza, Hans Björn Gehl, Federica Pediconi, Felix Diekmann, Wei Jun Peng, Lin Ma, Francesco Sardanelli, Paolo Belli, Stefano Corcione, Christian M. Zechmann, Matthieu Faivre-Pierret, Laura Martincich

Research output: Contribution to journalArticle

Abstract

Purpose To compare gadobenate dimeglumine-enhanced magnetic resonance imaging (MRI) with gadopentetate dimeglumine-enhanced MRI, mammography, and ultrasound for breast cancer detection across different malignant lesion types and across different densities of breast tissue. Materials and Methods In all, 153 women with Breast Imaging Reporting and Data System (BI-RADS) 3-5 findings on mammography and/or ultrasound underwent identical breast MRI exams at 1.5T with gadobenate dimeglumine and gadopentetate dimeglumine. Images were evaluated by three independent blinded radiologists. Mammography, ultrasound, and combined mammography and/or ultrasound findings were available for 108, 109, and 131 women. Imaging findings were matched with histology data by a fourth, independent, blinded radiologist. Malignant lesion detection rates and diagnostic performance were compared. Results In all, 120, 120, and 140 confirmed malignant lesions were present in patients undergoing MRI+mammography, MRI+ultrasound, and MRI+mammography and/or ultrasound, respectively. Significantly greater cancer detection rates were noted by all three readers for comparisons of gadobenate dimeglumine-enhanced MRI with mammography (Δ15.8-17.5%; P <0.0001), ultrasound (Δ18.3-20.0%; P <0.0001), and mammography and/or ultrasound (Δ8.6-10.7%; P ≤ 0.0105) but not for comparisons of gadopentetate dimeglumine-enhanced MRI with conventional techniques (P > 0.05). The false-positive detection rates were lower on gadobenate dimeglumine-enhanced MRI than on conventional imaging (4.0-5.5% vs. 11.1% at mammography; 6.3-8.4% vs. 15.5% at ultrasound). Significantly improved cancer detection on MRI was noted in heterogeneously dense breast (91.2-97.3% on gadobenate dimeglumine-enhanced MRI vs. 77.2-84.9% on gadopentetate dimeglumine-enhanced MRI vs. 71.9-84.9% with conventional techniques) and for invasive cancers (93.2-96.2% for invasive ductal carcinoma [IDC] on gadobenate dimeglumine-enhanced MRI vs. 79.7-88.5% on gadopentetate dimeglumine-enhanced MRI vs. 77.0-84.4% with conventional techniques). Overall diagnostic performance for the detection of cancer was superior on gadobenate dimeglumine-enhanced MRI than on conventional imaging or gadopentetate dimeglumine-enhanced MRI. Conclusion Gadobenate dimeglumine-enhanced MRI significantly improves cancer detection compared to gadopentetate dimeglumine-enhanced MRI, mammography, and ultrasound in a selected group of patients undergoing breast MRI for preoperative staging or because of inconclusive findings at conventional imaging. J. Magn. Reson. Imaging 2014;39:1272-1286. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1272-1286
Number of pages15
JournalJournal of Magnetic Resonance Imaging
Volume39
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • breast cancer
  • gadobenate dimeglumine-enhanced MRI
  • mammography
  • ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Fingerprint Dive into the research topics of 'Comparison of gadobenate dimeglumine-enhanced breast MRI and gadopentetate dimeglumine-enhanced breast MRI with mammography and ultrasound for the detection of breast cancer'. Together they form a unique fingerprint.

  • Cite this

    Gilbert, F. J., Van Den Bosch, H. C. M., Petrillo, A., Siegmann, K., Heverhagen, J. T., Panizza, P., Gehl, H. B., Pediconi, F., Diekmann, F., Peng, W. J., Ma, L., Sardanelli, F., Belli, P., Corcione, S., Zechmann, C. M., Faivre-Pierret, M., & Martincich, L. (2014). Comparison of gadobenate dimeglumine-enhanced breast MRI and gadopentetate dimeglumine-enhanced breast MRI with mammography and ultrasound for the detection of breast cancer. Journal of Magnetic Resonance Imaging, 39(5), 1272-1286. https://doi.org/10.1002/jmri.24434