Comparison of glucose vs. Glucose fat solutions in cancer patients: A controlled crossover study

F. Bozzetti, M. Ammatuna, S. Migliavacca, G. Facchetti, L. Cozzaglio, A. Morabito

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this investigation was to evaluate in a randomised crossover study the effects on nutritional status of two isonitrogenous-isocaloric regimens of total parenteral nutrition (TPN) in 12 severely cachectic cancer patients. The regimens consisted of (1) G: 50 kcal of glucose.kg-1.day-1 + 2g amino-acids.kg-1.day-1 (2) GL: 30 kcal glucose and 20 kcal lipids.kg-1 + 2g amino-acids.kg-1.day-1. Regimens G and GL were delivered sequentially for a period of 10 days each. Six patients (Group A) were randomised to receive regimen G first and regimen GL subsequently. In Group B patients the regimens alternated in the opposite way. The following nutritional variables were measured before TPN, after regimen G and after regimen GL: weight, arm circumference, arm muscle circumference, triceps skin fold, serum proteins, serum albumin, cholinesterase, transferrin, pre-albumin, retinol-binding protein, peripheral lymphocytes, cumulative nitrogen balance and mean urinary excretion of creatinine and 3-methylhistidine. The data showed that body weight and retinol-binding protein significantly increased with both G and GL regimens. No difference was found in the remaining variables, not even when comparing regimen G to GL. Increase in retinol-binding protein and in nitrogen balance were significantly better in the first period of treatment than in the second. These results show that the two regimens had a similar impact on the nutritional status of the cachectic cancer patients and choice between a glucose or a glucose-fat TPN should depend mainly on tolerance of the patients, duration and cost of therapy.

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalClinical Nutrition
Volume9
Issue number6
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)

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