Comparison of Halsted mastectomy with quadrantectomy, axillary dissection, and radiotherapy in early breast cancer: Long-term results

Umberto Veronesi, Alberto Banfi, Marcella del Vecchio, Roberto Saccozzi, Claudio Clemente, Marco Greco, Alberto Luini, Ettore Marubini, Giuseppe Muscolino, Franco Rilke, Virgilio Sacchini, Bruno Salvadori, Annamaria Zecchini, Roberto Zucali

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Abstract

From 1973 to 1980 we randomly assigned 701 patients with breast cancer measuring less than 2 cm in diameter and with no palpable axillary lymph nodes to Halsted radical mastectomy (n 349) or to 'quadrantectomy' with axillary dissection and radiotherapy to the ipsilateral breast tissue (n 352). The two groups were comparable in age distribution, size and site of primary tumor, menopausal status, and frequency of axillary metastases. The average follow-up time was 103 months. Actuarial curves show no difference between the two groups in the disease-free interval after surgery or in the overall survival rate. At 8 yr the disease-free survival was 77% for the patients in the Halsted group and 80% for those in the 'quadrantectomy' group, and the overall survival was 83 and 85% respectively. We conclude that small breast cancers may be safely treated with the conservative treatment described. In our opinion total ablative operations are not justified.

Original languageEnglish
Pages (from-to)1085-1089
Number of pages5
JournalEuropean Journal of Cancer and Clinical Oncology
Volume22
Issue number9
DOIs
Publication statusPublished - 1986

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ASJC Scopus subject areas

  • Oncology

Cite this

Veronesi, U., Banfi, A., del Vecchio, M., Saccozzi, R., Clemente, C., Greco, M., Luini, A., Marubini, E., Muscolino, G., Rilke, F., Sacchini, V., Salvadori, B., Zecchini, A., & Zucali, R. (1986). Comparison of Halsted mastectomy with quadrantectomy, axillary dissection, and radiotherapy in early breast cancer: Long-term results. European Journal of Cancer and Clinical Oncology, 22(9), 1085-1089. https://doi.org/10.1016/0277-5379(86)90011-8