Comparison of Hodgkin’s lymphoma in children and adolescents. A twenty year experience with MH’96 and LH2004 AIEOP (Italian association of pediatric hematology and oncology) protocols

Roberta Burnelli, Giulia Fiumana, Roberto Rondelli, Marta Pillon, Alessandra Sala, Alberto Garaventa, Emanuele S.G. D'amore, Elena Sabattini, Salvatore Buffardi, Maurizio Bianchi, Luciana Vinti, Marco Zecca, Paola Muggeo, Massimo Provenzi, Piero Farruggia, Francesca Rossi, Salvatore D'amico, Elena Facchini, Sayla Bernasconi, Raffaela De SantisTommaso Casini, Fulvio Porta, Irene D'alba, Rosamaria Mura, Federico Verzegnassi, Antonella Sau, Simone Cesaro, Katia Perruccio, Monica Cellini, Patrizia Bertolini, Domenico Sperlì, Roberta Pericoli, Daniela Galimberti, Adele Civino, Maurizio Mascarin

Research output: Contribution to journalArticle

Abstract

Adolescents and young adults (AYAs) represent a distinct group of patients. The objectives of this study were: To compare adolescent prognosis to that of younger children; to compare the results achieved with the two consecutive protocols in both age groups; to analyze clinical characteristics of children and adolescents. Between 1996 and 2017, 1759 patients aged <18 years were evaluable for the study. Five hundred and sixty patients were treated with the MH’96 protocol and 1199 with the LH2004 protocol. Four hundred and eighty-two were adolescents aged ≥15 years. Patients in both age groups showed very favorable prognoses. In particular, OS improved with the LH2004 protocol, especially in the adolescent group and in the low risk group, where radiation therapy was spared. Adolescent characteristics differed significantly from the children’s according to sex, histology, and the presence of symptoms. Remarkable is the decrease both in mixed cellularity in the children and in low stages in both age groups in the LH2004 protocol with respect to MH’96 protocol. Based on our experience, adopting pediatric protocols for AYA does not compromise patient outcomes.

Original languageEnglish
Article number1620
Pages (from-to)1-20
Number of pages20
JournalCancers
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Adolescent
  • Chemotherapy
  • Children
  • Clinical characteristics
  • Histology
  • Hodgkin’s lymphoma
  • Pediatric
  • Prognosis
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Burnelli, R., Fiumana, G., Rondelli, R., Pillon, M., Sala, A., Garaventa, A., D'amore, E. S. G., Sabattini, E., Buffardi, S., Bianchi, M., Vinti, L., Zecca, M., Muggeo, P., Provenzi, M., Farruggia, P., Rossi, F., D'amico, S., Facchini, E., Bernasconi, S., ... Mascarin, M. (2020). Comparison of Hodgkin’s lymphoma in children and adolescents. A twenty year experience with MH’96 and LH2004 AIEOP (Italian association of pediatric hematology and oncology) protocols. Cancers, 12(6), 1-20. [1620]. https://doi.org/10.3390/cancers12061620