TY - JOUR
T1 - Comparison of Hodgkin's Lymphoma in Children and Adolescents. A Twenty Year Experience with MH'96 and LH2004 AIEOP (Italian Association of Pediatric Hematology and Oncology) Protocols
AU - Burnelli, Roberta
AU - Fiumana, Giulia
AU - Rondelli, Roberto
AU - Pillon, Marta
AU - Sala, Alessandra
AU - Garaventa, Alberto
AU - D'Amore, Emanuele S G
AU - Sabattini, Elena
AU - Buffardi, Salvatore
AU - Bianchi, Maurizio
AU - Vinti, Luciana
AU - Zecca, Marco
AU - Muggeo, Paola
AU - Provenzi, Massimo
AU - Farruggia, Piero
AU - Rossi, Francesca
AU - D'Amico, Salvatore
AU - Facchini, Elena
AU - Bernasconi, Sayla
AU - De Santis, Raffaela
AU - Casini, Tommaso
AU - Porta, Fulvio
AU - D'Alba, Irene
AU - Mura, Rosamaria
AU - Verzegnassi, Federico
AU - Sau, Antonella
AU - Cesaro, Simone
AU - Perruccio, Katia
AU - Cellini, Monica
AU - Bertolini, Patrizia
AU - Sperlì, Domenico
AU - Pericoli, Roberta
AU - Galimberti, Daniela
AU - Civino, Adele
AU - Mascarin, Maurizio
PY - 2020/6/18
Y1 - 2020/6/18
N2 - Adolescents and young adults (AYAs) represent a distinct group of patients. The objectives of this study were: To compare adolescent prognosis to that of younger children; to compare the results achieved with the two consecutive protocols in both age groups; to analyze clinical characteristics of children and adolescents. Between 1996 and 2017, 1759 patients aged <18 years were evaluable for the study. Five hundred and sixty patients were treated with the MH'96 protocol and 1199 with the LH2004 protocol. Four hundred and eighty-two were adolescents aged ≥15 years. Patients in both age groups showed very favorable prognoses. In particular, OS improved with the LH2004 protocol, especially in the adolescent group and in the low risk group, where radiation therapy was spared. Adolescent characteristics differed significantly from the children's according to sex, histology, and the presence of symptoms. Remarkable is the decrease both in mixed cellularity in the children and in low stages in both age groups in the LH2004 protocol with respect to MH'96 protocol. Based on our experience, adopting pediatric protocols for AYA does not compromise patient outcomes.
AB - Adolescents and young adults (AYAs) represent a distinct group of patients. The objectives of this study were: To compare adolescent prognosis to that of younger children; to compare the results achieved with the two consecutive protocols in both age groups; to analyze clinical characteristics of children and adolescents. Between 1996 and 2017, 1759 patients aged <18 years were evaluable for the study. Five hundred and sixty patients were treated with the MH'96 protocol and 1199 with the LH2004 protocol. Four hundred and eighty-two were adolescents aged ≥15 years. Patients in both age groups showed very favorable prognoses. In particular, OS improved with the LH2004 protocol, especially in the adolescent group and in the low risk group, where radiation therapy was spared. Adolescent characteristics differed significantly from the children's according to sex, histology, and the presence of symptoms. Remarkable is the decrease both in mixed cellularity in the children and in low stages in both age groups in the LH2004 protocol with respect to MH'96 protocol. Based on our experience, adopting pediatric protocols for AYA does not compromise patient outcomes.
U2 - 10.3390/cancers12061620
DO - 10.3390/cancers12061620
M3 - Article
C2 - 32570974
VL - 12
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 6
M1 - 1620
ER -