TY - JOUR
T1 - Comparison of iodinated contrast media for the assessment of atherosclerotic plaque attenuation values by CT coronary angiography
T2 - Observations in an ex vivo model
AU - La Grutta, Ludovico
AU - Galia, M.
AU - Gentile, G.
AU - Lo Re, G.
AU - Grassedonio, E.
AU - Coppolino, F.
AU - Maffei, E.
AU - Maresi, E.
AU - Lo Casto, A.
AU - Cademartiri, F.
AU - Midiri, M.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Objective: To compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography. Methods: In six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64x0.625mm, temporal resolution 210 ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (Iodixanol 320 mgI ml-1) and a monomeric high-iodinated contrast medium (Iomeprol 400 mgI ml-1) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated. Results: Both contrast media showed different attenuation values within lumen and plaque (p0.05). Conclusion: Differently iodinated contrast media have a similar influence on plaque attenuation profiles. Advances in knowledge: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging.
AB - Objective: To compare the influence of different iodinated contrast media with several dilutions on plaque attenuation in an ex vivo coronary model studied by multislice CT coronary angiography. Methods: In six ex vivo left anterior descending coronary arteries immersed in oil, CT (slices/collimation 64x0.625mm, temporal resolution 210 ms, pitch 0.2) was performed after intracoronary injection of a saline solution, and solutions of a dimeric isosmolar contrast medium (Iodixanol 320 mgI ml-1) and a monomeric high-iodinated contrast medium (Iomeprol 400 mgI ml-1) with dilutions of 1/80 (low concentration), 1/50 (medium concentration), 1/40 (high concentration) and 1/20 (very high concentration). Two radiologists drew regions of interest in the lumen and in calcified and non-calcified plaques for each solution. 29 cross-sections with non-calcified plaques and 32 cross-sections with calcified plaques were evaluated. Results: Both contrast media showed different attenuation values within lumen and plaque (p0.05). Conclusion: Differently iodinated contrast media have a similar influence on plaque attenuation profiles. Advances in knowledge: Since iodine load affects coronary plaque attenuation linearly, different contrast media may be equally employed for coronary atherosclerotic plaque imaging.
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U2 - 10.1259/bjr.20120238
DO - 10.1259/bjr.20120238
M3 - Article
C2 - 23255542
AN - SCOPUS:84871874377
VL - 86
JO - British Journal of Radiology
JF - British Journal of Radiology
SN - 0007-1285
IS - 1021
M1 - 20120238
ER -