Comparison of levels of HIV-1 resistance to protease inhibitors by recombinant versus conventional virus phenotypic assay and two genotypic interpretation procedures in treatment-naive and HAART-experienced HIV-infected patients

Research output: Contribution to journalArticle

Abstract

Objectives: To compare genotypic and phenotypic HIV-1 drug resistance assays. Methods: Protease inhibitor (PI) susceptibility was phenotypically analysed in HIV-1 isolates and recombinant viruses expressing proteases from viral isolates. Two genotypic interpretation methods were carried out in parallel. Results: Entirely concordant resistance levels were shown in 5/10 (50%) highly active antiretroviral therapy (HAART)-experienced patients, Conclusions: The four assays provide comparable results. The recombinant virus phenotypic assay may provide the most accurate evaluation of resistance; however, genotypic interpretation procedures are helpful for daily therapeutic decisions.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalJournal of Antimicrobial Chemotherapy
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 2003

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

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