Comparison of mathematical models for red marrow and blood absorbed dose estimation in the radioiodine treatment of advanced differentiated thyroid carcinoma

A. Miranti; A. Giostra; E. Richetta; E. Gino; R. E. Pellerito; M. Stasi

doi:10.1088/0031-9155/60/3/1141

Comparison of mathematical models for red marrow and blood absorbed dose estimation in the radioiodine treatment of advanced differentiated thyroid carcinoma

A. Miranti, A. Giostra, E. Richetta, E. Gino, R. E. Pellerito, M. Stasi

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Metastatic and recurrent differentiated thyroid carcinoma is preferably treated with ¹³¹I, whose administered activity is limited by red marrow (RM) toxicity, originally correlated by Benua to a blood absorbed dose higher than 2 Gy. Afterward a variety of dosimetric approaches has been proposed. The aim of this work is to compare the results of the Benua formula with the ones of other three blood and RM absorbed dose formulae. Materials and methods have been borrowed by the dosimetric protocol of the Italian Internal Dosimetry group and adapted to the routine of our centre. Wilcoxon t-tests and percentage differences have been applied for comparison purposes. Results are significantly different (p

Original language	English
Pages (from-to)	1141-1157
Number of pages	17
Journal	Physics in Medicine and Biology
Volume	60
Issue number	3
DOIs	https://doi.org/10.1088/0031-9155/60/3/1141
Publication status	Published - Feb 7 2015

Keywords

advanced thyroid cancer
blood and red marrow dosimetry
comparison
dose-response
I-131
internal dosimetry

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology
Medicine(all)

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10.1088/0031-9155/60/3/1141

Cite this

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abstract = "Metastatic and recurrent differentiated thyroid carcinoma is preferably treated with 131I, whose administered activity is limited by red marrow (RM) toxicity, originally correlated by Benua to a blood absorbed dose higher than 2 Gy. Afterward a variety of dosimetric approaches has been proposed. The aim of this work is to compare the results of the Benua formula with the ones of other three blood and RM absorbed dose formulae. Materials and methods have been borrowed by the dosimetric protocol of the Italian Internal Dosimetry group and adapted to the routine of our centre. Wilcoxon t-tests and percentage differences have been applied for comparison purposes. Results are significantly different (p",

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AU - Miranti, A.

AU - Giostra, A.

AU - Richetta, E.

AU - Gino, E.

AU - Pellerito, R. E.

AU - Stasi, M.

PY - 2015/2/7

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Comparison of mathematical models for red marrow and blood absorbed dose estimation in the radioiodine treatment of advanced differentiated thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

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