Abstract
Metastatic and recurrent differentiated thyroid carcinoma is preferably treated with 131I, whose administered activity is limited by red marrow (RM) toxicity, originally correlated by Benua to a blood absorbed dose higher than 2 Gy. Afterward a variety of dosimetric approaches has been proposed. The aim of this work is to compare the results of the Benua formula with the ones of other three blood and RM absorbed dose formulae. Materials and methods have been borrowed by the dosimetric protocol of the Italian Internal Dosimetry group and adapted to the routine of our centre. Wilcoxon t-tests and percentage differences have been applied for comparison purposes. Results are significantly different (p
Original language | English |
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Pages (from-to) | 1141-1157 |
Number of pages | 17 |
Journal | Physics in Medicine and Biology |
Volume | 60 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 7 2015 |
Keywords
- advanced thyroid cancer
- blood and red marrow dosimetry
- comparison
- dose-response
- I-131
- internal dosimetry
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
- Medicine(all)