Comparison of mathematical models for red marrow and blood absorbed dose estimation in the radioiodine treatment of advanced differentiated thyroid carcinoma

A. Miranti, A. Giostra, E. Richetta, E. Gino, R. E. Pellerito, M. Stasi

Research output: Contribution to journalArticle

Abstract

Metastatic and recurrent differentiated thyroid carcinoma is preferably treated with 131I, whose administered activity is limited by red marrow (RM) toxicity, originally correlated by Benua to a blood absorbed dose higher than 2 Gy. Afterward a variety of dosimetric approaches has been proposed. The aim of this work is to compare the results of the Benua formula with the ones of other three blood and RM absorbed dose formulae. Materials and methods have been borrowed by the dosimetric protocol of the Italian Internal Dosimetry group and adapted to the routine of our centre. Wilcoxon t-tests and percentage differences have been applied for comparison purposes. Results are significantly different (p

Original languageEnglish
Pages (from-to)1141-1157
Number of pages17
JournalPhysics in Medicine and Biology
Volume60
Issue number3
DOIs
Publication statusPublished - Feb 7 2015

Keywords

  • advanced thyroid cancer
  • blood and red marrow dosimetry
  • comparison
  • dose-response
  • I-131
  • internal dosimetry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

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