Comparison of metabolic effects of orlistat and sibutramine treatment in Type 2 diabetic obese patients

Giuseppe Derosa, A. F G Cicero, G. Murdolo, L. Ciccarelli, R. Fogari

Research output: Contribution to journalArticlepeer-review


Aim: The aim of our study was to comparatively evaluate the efficacy and safety of orlistat and sibutramine treatment in obese diabetic patients of both sexes, with specific attention to metabolic pattern-induced changes and cardiovascular effects. Methods: Patients were enrolled, evaluated, and followed in 3 Italian Centres of Internal Medicine. We evaluated 144 obese diabetic patients. All were required to have been diagnosed as being diabetic for at least 6 months, and had glycaemic control with diet alone or diet and oral hypoglycaemic agents. We administered orlistat (360 mg/d) or sibutramine (10 mg/d) in a randomized, controlled, double-blind clinical study, and evaluated anthropometric variables, glycaemic control, blood pressure and heart rate (HR) during 12 months of this treatment. Results: A total of 141 (69 males and 72 females; 35 males and 36 females, aged 53±5 yr with orlistat; 34 males and 36 females, aged 51±4 yr with sibutramine) completed the 4 weeks on controlled-energy diet and were randomized to double-blind treatment with orlistat (n=71) or sibutramine (n=70). Significant body mass index (BMI) improvement was present after 6 (p1c decrease was obtained after 6 (p

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalDiabetes, Nutrition and Metabolism - Clinical and Experimental
Issue number4
Publication statusPublished - Aug 2004


  • Diabetes mellitus
  • Obesity
  • Orlistat
  • Safety
  • Sibutramine
  • Type 2

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine


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