Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography

A Rabiolo, F Gelormini, R Sacconi, MV Cicinelli, Giacinto Triolo, P Bettin, K Nouri-Mahdavi, F Bandello, G Querques

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Purpose To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. Methods Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. Results Healthy eyes exhibited higher vessel density values in all plexuses compared to diseased eyes regardless of the algorithm used (p
Original languageEnglish
Article numbere0205773
JournalPLoS One
Issue number10
Publication statusPublished - 2018


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