Comparison of MR pulse sequences in the detection of multiple sclerosis lesions

Tarek A. Yousry, Massimo Filippi, Christoph Becker, Mark A. Horsfield, Raymond Voltz

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare the sensitivity of conventional spin-echo, fast spin-echo, fast fluid-attenuated inversion recovery (FLAIR), and turbo gradient spin-echo MR sequences in the detection of multiple sclerosis lesions. METHODS: Conventional spin-echo, fast spin-echo, fast FLAIR, and turbo gradient spin-echo sequences were performed on a 1.0-T MR imager in seven patients with clinically definite multiple sclerosis. The images in each sequence were evaluated by two raters and consensus was reached by agreement. RESULTS: In comparing conventional spin-echo with fast spin-echo sequences, five lesions were seen only by conventional spin-echo and 63 were seen only by fast spin-echo; in comparing conventional spin-echo with fast FLAIR sequences, 18 lesions were seen only by conventional spin-echo and 109 only by fast FLAIR; in comparing conventional spin-echo with turbo gradient spin-echo sequences, 51 lesions were seen only by conventional spin-echo and seven only by turbo gradient spin-echo; in comparing fast spin-echo with fast FLAIR sequences, 45 lesions were seen only by fast spin-echo and 52 only by fast FLAIR. CONCLUSION: Fast spin-echo and fast FLAIR sequences improve the sensitivity of MR imaging in the detection of multiple sclerosis lesions with reduced acquisition time as compared with conventional spin-echo sequences. These sequences should therefore be considered for serial studies in patients with multiple sclerosis. The sensitivity of turbo gradient spin-echo was inferior to the other sequences, but its reduced acquisition time could make this technique the ideal choice for patients who cannot tolerate longer examination times.

Original languageEnglish
Pages (from-to)959-963
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume18
Issue number5
Publication statusPublished - May 1997

Keywords

  • Magnetic resonance,technique
  • Sclerosis, multiple

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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  • Cite this

    Yousry, T. A., Filippi, M., Becker, C., Horsfield, M. A., & Voltz, R. (1997). Comparison of MR pulse sequences in the detection of multiple sclerosis lesions. American Journal of Neuroradiology, 18(5), 959-963.