Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems

Enrico Tortoli, Romano Mattei, Arnaldo Savarino, Laura Bartolini, Jörg Beer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The recently introduced automated culture systems MB/BacT (Organon Teknika, Belgium) was compared with radiometric BACTEC 460TB (Becton Dickinson, USA) to test antimicrobial susceptibility of Mycobacterium tuberculosis to first line drugs. On 113 strains 97.5% agreement was obtained, with the difference being not significant. Concordance was practically complete for the most important drugs, isoniazid and rifampin. The two methods however significantly differed for the time needed to complete the test; in fact MB/BacT required on the average five days more than BACTEC 460TB. Despite the delay in the completion of the test, the excellent reliability along with the elimination of radioactivity and full automation make MB/BacT an attractive alternative for susceptibility testing of M. tuberculosis. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalDiagnostic Microbiology and Infectious Disease
Volume38
Issue number2
DOIs
Publication statusPublished - Oct 2000

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Mycobacterium tuberculosis
Automation
Belgium
Isoniazid
Rifampin
Pharmaceutical Preparations
Radioactivity

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems. / Tortoli, Enrico; Mattei, Romano; Savarino, Arnaldo; Bartolini, Laura; Beer, Jörg.

In: Diagnostic Microbiology and Infectious Disease, Vol. 38, No. 2, 10.2000, p. 83-86.

Research output: Contribution to journalArticle

Tortoli, Enrico ; Mattei, Romano ; Savarino, Arnaldo ; Bartolini, Laura ; Beer, Jörg. / Comparison of Mycobacterium tuberculosis susceptibility testing performed with BACTEC 460TB (Becton Dickinson) and MB/BacT (Organon Teknika) systems. In: Diagnostic Microbiology and Infectious Disease. 2000 ; Vol. 38, No. 2. pp. 83-86.
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