Comparison of myocardial deformation and velocity dyssynchrony for identification of responders to cardiac resynchronization therapy

Donato Mele, Tiziano Toselli, Fabio Capasso, Giuseppe Stabile, Marcello Piacenti, Massimo Piepoli, Sara Giatti, Catherine Klersy, Luciano Sallusti, Roberto Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

AimsIt is unclear whether myocardial velocity or deformation indices of dyssynchrony are better at predicting response to cardiac resynchronization therapy (CRT). Therefore, two indices of left ventricular (LV) dyssynchrony based on myocardial velocity and deformation were compared to predict success of CRT.Methods and resultsSixty patients with dilated cardiomyopathy, New York Heart Association class III-IV, LV ejection fraction (EF) ≤35, QRS >120 ms underwent CRT. The standard deviation of the averaged time-to-peak longitudinal negative strain (Tε-SD) and positive systolic velocity (Tv-SD) of 12 LV segments were calculated before and after 6 months of CRT. Responders were defined at month 6 by ≥20 EF increase and/or ≥15 end-systolic volume (ESV) decrease with respect to baseline. On univariable analysis, baseline Tε-SD and Tv-SD were both significantly associated with CRT response; however, the area under the receiver operating characteristic curve was better for Tε-SD. On bivariable analysis, only Tε-SD retained an independent prognostic value for CRT response. Results of the analysis did not change when the logistic models were adjusted for aetiology.ConclusionBaseline dyssynchrony of longitudinal myocardial peak deformation (Tε-SD) appears to be better than dyssynchrony of longitudinal myocardial peak systolic velocities (Tv-SD) for the identification of CRT responders.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalEuropean Journal of Heart Failure
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Biventricular pacing
  • Cardiac resynchronization therapy
  • Doppler tissue imaging
  • Heart failure
  • Strain imaging

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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